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A . <br /> oils <br /> o6-2n <br /> _"G�'�=Gt�ne (2•'-.4-tr�ernplpenta:.e) <br /> The iso-Qcranc$ are Wodarately toxic by Zha Oral <br /> asnu3ced i:1L0 the lungs 4L rats, t =Out,. if <br /> wnea n ected ev will cause pulmo '_esioas. <br /> �� j .at-amlLscularly �.to :a:,bi:^, -50-Octane <br /> e=-- o Se, edema. ::zccrsti4isl w =nnumoairis, °-octane Produced <br /> xis and fibrosis. Iahalatioa oz 16.000 PD= causedbscess =nr-a`ion, <br /> arrest in mice and 5 aiaztes ernosure to 1000 Ppm wa; highly_espixatory <br /> (1937). €b Y irritating <br /> veth� onenrane <br /> :iethylcgelopeatane es les cgcloventane in its rozieitp_ <br /> CYclOPenrane is a CAIS dapressant, Kt s can tolerate 10-15 ppm. In <br /> Mce, 3g � cJ.uses loss a£ rQflexes, <br /> that no safe =arr-Osial and death demonstrating <br /> zF margin exists- Yethylcpclonencane also <br /> 33fcty Margin between the onset of exhibits <br /> guinea nig skin, cticlopentano narcosis and zr+anh. loco applied .a <br /> Methylcyc.lcpentaue could Produced dryness and s1i9nz. erythema. <br /> he e;peCtcd to have the carpe e:�er s'.L)• <br /> Net(-v1 clohexa e - <br /> No "stemic plisoning, by eothylcyclohe=ne nave been reported i:t <br /> At bi8b Vapor conceatra=iota it cruses narcosis in <br /> is expected would produce 2new+J.s and it <br /> xP el c it wo tho same effect in hum:las. The <br /> no-effect level is about 300 ppb in primates and 3200 <br /> Rabbits did not survive 70 PPO in rabbirs. <br /> was miacong of ezpostLre to 15,227 Ppm, Death <br /> Preceded by conjunctival congestion, dpspnea. severe convulsions <br /> and rapid narcosis. Thera were no <br /> exposed cc 2880 ppm for a sign= of intoxication in rAbbits <br /> vzx observed in total of 90 hours, but slight cellular ?njyQy <br /> concentrations the livor sed murousand lddaeys. Ia Primates, lethal <br /> labored breathing =d diarrhea. sacrocion, lacrimacion, salivation. <br /> Ia chronic inhalation studies, exna�urc to 2000 rpm, fi hours <br /> day. S days par week rot Y vroeu <br /> Years ted no ~smears in _ Per <br /> cams=er. <br /> or dogs. The only s1gmzficanc toxic effect fQundJwas rena.i <br /> cnartges in =ale rats. :'tiesQ included renal t <br /> hvperplasic and medullasv abula; d_33rion. ?anfllary <br /> +ainaralizatiun. . <br /> Dermal application (f he 11iqu.Ld .rocuced ioc.1 <br /> :sickening and ulca - - <br /> 1 Cyclobarane _ <br /> +5 <br /> acL•LC c;Pmosurc are ,pxc.L z, ryC loss <br /> nt P 11br_�1Ci_; Symmto= of <br /> `- �relY, death rastLics clue of epui s=avor <br /> cc r ospirator/ r+. ane coma. <br /> is induced is wa4k and o =chute. a anesthesia which <br /> caused b brie du=acicn but =ore potent than that <br /> q hexane, :ho a�rai L?Lo in rabbits : meas ran <br /> eJ/kz. iiiC.tsin ?-5 holir- the ani=ls z-xibi 4ed severe <br /> '' '.ridespread �•ascular ciamaca :creel s <br /> diary+ea. <br /> coI_aose• Deeererat•-- <br /> - -•z _asio:Ls were <br /> tl <br /> _ -• 6/87 <br />