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G <br /> MAN <br /> "' -- 0--LS 50-28 <br /> ''"' 3en•^eae <br /> Ethyl benzene is prirxrily an it tanc co the skin. a_�es and utroer <br /> =esairatory trst=. S •Swam c aosorom,ic. ca-uses CN-S deuressioa 4 <br /> For earn razor^-.at,on, zefer to C'a-pter 20 of zhe Ia.sralla=-on <br /> Resroration r2rograa Toxicology Guide, d?olure I. <br /> __ Tr`-�er_hy]3�enzenea <br /> The trinerhylbenxenes occur is 3 isomeric Tozms. The 1.3,5-isoner <br /> (mesitylene) and the 1,2,4-isoraer (pseudocumenel are coucologically <br /> siailaz- High vapor concentrations (5000-9000 ppm) cess CUS <br /> depression in a=j=a Loss of raflexes was seen in mice exposod to <br /> _ 8130-9140 ppa of rhe 1.2,4-isomer or 8130 ppm of the 1,3,5-1somer. <br /> Sats ernosed to 1700 ppm of an isomeric aixture for 10-21 days had no <br /> adverse effects or fatalities. <br /> The fatal intraperitameal dose o= the 1..2.4-isomer for the guinea <br /> Pig is 1.788 g/kg, while the fatal dose of rhe •1.3,5-isomer 3y tha s=e <br /> route is 1.5-2 g/kg for the rat. For the 1,2.3—isomer— a= arai LDLo of <br /> 5000 ME,/q has been reported in the rat. Tzl=achylbenzene liquid is a <br /> prirsry skin irritant. Depasitien into the lungs causes pneumoniris az <br /> the site of contact_ <br /> The only report of hump exposure described symptoms of <br /> nexvousne", tension, amciety asthmat_c bronchiwis, hypochromic anemia <br /> and rhange_i in the caagul,+biliLp of t <br /> ranged from IO-b0 ppm. he blood. Vapor cor_centrations <br /> Exposure Was to a mixture containing 30% of the <br /> 1.3,3-isomer and 503 of the 3,2,4-isomer (2,12). <br /> jLethYlnaahrhalene <br /> s., The only adverse effCcts of nerhylnaphthalene reported in man are <br /> skin irritation and photosenSiti=ar-ion' (17)_ Oral iDSQ values of 1840 <br /> mg/kg and 1630 mg/kg have been reported for ?-methvlrapathzlene and <br /> p.. <br /> 2-methylnaphthalene, respectively, is the rat (47), <br /> t <br /> Vavhthalene <br /> • ingestion or prolonged inhalation of naphthalene produces nausea, <br /> vomiting and disorientation. Ic is irritating ca the skin and eyes and <br /> prolonged vapor exposure has led to cat=racz formation i uaans (17). <br /> :3emalysic anemia i, the most severe ef?ect associated -:th naphthalene <br /> exposure, but this effect is seen predo=inaautly in individuals with an <br /> enn me deficiency (54), <br /> •- For more infarmacion, refer to C%oter 32 of the installation <br /> Restoration. Toxicology Guide, Volume 1. <br /> 5/87 <br />