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-��, - �-2 <br /> iz <br /> e <br /> k� <br /> M <br /> FutL OILS <br /> 66-27 <br /> seen in the heart, lung, liver, kidney and brain. A one-holt vapor <br /> exposure to 26,752 ppm caused rapid narcosis and tremor and was lethal <br /> to all exposed rabbits. In nice, concentratiors causing narcosisp •.ary <br /> from 14,600 to 122.000 am. <br /> Cyclohexane is nominally absorbed through the skin although <br /> massive applications (> 180.2 9/kg) to rabbit skin resulted in <br /> microscopic changes in the liver and kidneys and caused the death of <br /> all animals. <br /> The danger of chronic poisoning is relatively slight because this <br /> compound is almost completely eliminated from the body. No toxic <br /> changes were seen in rabbits exposed to vapor levels of 434. ppm, 6 <br /> hours daily for 50 exposures, but some microscopic changes were seen in <br /> the lifer and kidneys when the exposure was to 786 ppm for. the same <br /> period. <br /> ~ In man, no systemic poisonings by cyclohexane have been reported. <br /> A vapor level of 300 ppm is somewhat irritating to the eyes and mucous <br /> membranes. It has been reported that cvciohexane may potentiate the <br /> toxic effects of TOCP but no additional details of this interaction are <br /> available (12,17,46,54,1937), <br /> {•� r e <br /> - Thr, primary effects of benzene inhalation and ingestion are an the <br /> central nervous system (54). Benzene is carcinogenic in both animals <br /> , 9 and man. Several reports have established a relationship between <br /> M� benzene exposure and leukemia. For more information, refer to Chapter <br /> 18 of the Installation Restoration Program Toxicoloey Guide, Volume 1. <br /> Lo-Lu Ln—e <br /> ► Toluene is a CNS depressant with a low toxicity. Fot_ more <br /> information,. refer to Chapter 19 of the Installation Restoration <br /> Program Toxicology Guide, Volume 1. <br /> Acute exposure to high concentrations of xylene vapors may cause <br /> CNS depression. Both tae liquid and the vapor are it;icating to the <br /> S <br /> eyes, raucous membranes and skin (46). The Naticnal Toxicology Program <br /> recently reported that there was no evidence of carcinogenicity of <br /> mixed xylenes in either mice or rats given daily doses ranging from 250 <br /> co 1000 mg/kg by gava¢e for 2 years (1939) . <br /> /ir <br /> For more information, refer to Chapter 21 of the Installation <br /> Restoration Programs Toxicology Guide, volume L- <br /> e <br /> 6/87 <br />