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M� - 1011=0 a �.a cL OILS ' 66-21 duration of exposure, Dose-reiaced effects in nourol°gical tasting a indicate that the uncombusced diesel vapors easy also ace xt aeurodepressant (2334) . In acute dermal studies conducted in ranbies, number 6 heavy oil (API gravity 5.2/1•23 sulfur) induced significant sign, fuel at 5 9/kg' It causr;d severe dermal irritation, Brei t °f toxicity ataxia and lethar gh loss, anoraxia„ lethargy. Korcalit•/ Mas 37,5%. Necropsy revealed scuta toxic hepatitis, gastroincescinal irritation and congested lung=. Ocher grades of number. 6 and number 2 oils as well as diesel oil produced mild to moderate dermal irritation but no systemic signs of toxicity (1924), • In the subacute dermal study, doses ranging from 1 c° 10 ml/kg were applied to rabbits clipped free of hair. The area remained bandaged for 24 hours at which cine the patches were removed and a new dose applied. This continued for 5 consecutive dans followed by a 2 day rest period end a reputi•re dove. In eat application for 5 consee this test, the number 6 Euel oil (API gravity produced 5.1/1.23 sulfur) the greatest degree of toxicity at the lowest dace (755 mortality ed 2.5 mL/kg), Clinical signs iac ncic,ded severe weight loss, anorrxia and Signs of dermal irritation, Cross necropsy revealed hemorrhagic gastroenteritis, and congested, mottled livers with multifocal ecrosis and centrilobular vacuolar degeneration. In aLI cases, the number 6 oils caused inflautmacion, dermal congestion and edema, dermal necrosis, acanthosis and parakeracosis. Liver necrosis and degeneration were also seen but the sevet-ity was not as Ereat as that with 5.1/1.21 sulfur. All 3 number 2 oils cathed weight loss, anorexia and various degrees of dermal irritacion. At a dose of 10 mL/kg, mortality ranged from 75 c° 1001. Cross necropsy Lesions at all dosage levels iiieluded re,;-+ and hepatic congestion. At the 10 mL/kg level, multifocal +" .Apatie necrosis was observed (1924). In primary dermal irritation tests, the number 2 oils were moderately irritating while the rumbex '6 oils were minimally cc slightly irritating. Diesel fuel was extremely irritating. Signs included severe erythema and edema with blistering and open sores. The test was conducted by applying 0.5 mL of unt:iluted material to abraded rabbit skin. The cast was then covered for 24 hours at which point the bandage was removed and the animals scored according to the Drai-e technique (1924), i The number 6 oils were minimally co moderately irricacing when 0.1 ` mL vas applied to rabbit e;res. These materials produced conjunctival redness, swelling and discharge. Few corneal opacities «ere produced I but eyes returned to normal 'lithin 72 hours. Diesel fuel was noxi-irritating and number 2 oils ranged from practically non-irritating <� to mildly irricacing (1924). • J i 6/87 p