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FEM 0�5 <br /> i+ <br /> ' 66.3.1.x.2 Chxonic Totiic�-7 <br /> '_7o studies were rouaci regarding the chronic coziciL-r a= �ci ails <br /> in ani=23s. <br /> 66.3.2 +s " aid Epidemzoiogic Studies r <br /> 66.3.2.1 Shore-terse Toxicologic affects <br /> The chief syscd_,-:'C reaction to ve=oleum hydrecarbons, such as <br /> z'uel °its. is eantral nervaus system depression C17) . Toxacologica! <br /> effects ars exnecsad to resemble chose of kerosene; Ji.e., a lou oral, <br /> modsratc darmal, and high aspiration payard (12)• Provided that <br /> aspiressiar► does eat occur. :hs mean oral :et3u1 dose or kerosene for an <br /> adult is ascisasted to be 4 to 6 oaacas. go++ever, trice this 7). has <br /> caused death (17). This <br /> been tolerated. and less than k ° ca has <br /> s is lass. rabbits and guinea <br /> estim8tn map be lav since oral Asa death =y occur ui�hin 2 to <br /> Pigs aacced 20 =L/kg. Ir, fatal moisoni.angs. lea eras Of zxnecmpii- <br /> 24 hours after ingeacion. The dif,ercnea but e <br /> cared ingestions and the lethal 8sse where Tsoiration occurs may be as <br /> groat: as a pine and a resspaaniul. The fatChaal <br /> b oaccopneumonia. rKerosea <br /> from aspiration is an acute and often fatal p <br /> and related hydrocarbons ars also irritating ro she ricin and zrseays <br /> mrnbratvas. Percutaneous absorption Oxy be signific`c (17). <br /> ph <br /> Deal exposure to diesel oil has caused neover several weeks <br /> Dental a-ty• A mea <br /> who cleaned `^ZS tends and arcs with diesel oil over <br /> F experienced s. moms of epigastric and loin 'Pain- <br /> nausea, <br /> nopcutia, <br /> nausea, zaarexrr; scrotal swelling, severe exhausri°n and pitting ankle <br /> edsaa. Rana], biopsy revealed &curs tubular necrosis with psY <br /> degeneration and necrosis of ;he Pro%'=' and distal �sbular cpiths who <br /> (1314). Another case was described by Barxientos er ate-• (1815) <br /> reporcad aau.ta oliguric failure in a 1 ed t� who had washed how his bait <br /> with diesel oil. A renal biopsy performed the nrxt dry shoved tul�. <br /> dilation and a p;.aliferatioa ur crslls iesult z ;hn = alati n oz diesel <br /> naphrocomic, etfecrs were rmportAd as a r <br /> oil vapors in a z--u&. cab over a 10 dap Period (1516)' <br /> } <br /> -Liquid petraleum hydrocarbons cause little or no is . on direct <br /> Um <br /> eye contact_ Kerosene and veL=oleum oil on rabbit and unan corneas <br /> are essentially innocuous <br /> 66.3.2.2 Chronic Toxicologic EFFacrz <br /> arfecL °= re <br /> No Ytudies were found which eva3uated the studies <br /> exposure to fuel oils. However. • numerous enidem-telegy <br /> n cndcted. <br /> evaluaL7,S the effects of perrnleum, exposure =naCe`a ins toobeulower <br /> zhilt most: have shown overall stanGardi:ed morts_iry hav <br /> rhea those of the general population. elevated number these d ar at=ons <br /> been observed for cancers at several sites. However. <br /> C=c <br /> crs have been <br /> are not. =ound consistznrly in all Of the studies. <br /> 6/87 <br /> ��ae� -i[ii911 <br />