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'".'2±#.tY': <br /> eo <br /> l <br /> uLL OILS <br /> brae�Y'ed in C a ion 66-23 <br /> 11, skin, ; g' nasal cavity-and noses, <br /> 66 <br /> been reported (18I7)as and kidnev. Leukemias and l}�homaive system. <br /> 3.3 s have also <br /> Toxicology or Fuel Oil Comoonencs <br /> A brief <br /> ov . <br /> ecmaonents e iew of the <br /> of fuel oils are summartz ad"abelow of the Tma)or hydrocarbon <br /> (see able 56_5) <br /> hexane may be <br /> ingested, is the most highly <br /> irritation Causes nausea, member of t <br /> Y toxic <br /> hazard, and CVS eafects,Vercigo, bronchial and he alkanes. when <br /> Non-speeificauce exposure occucxaiSo presents an acute eneral lntescinal <br /> nac the firsr tPrco; ouch as vertigo. through iasPiratlon <br /> osis-like be marl $O' headache, nausea nhalarlon, <br /> :tate fested, At Pre. State <br /> appears as resole gh and vo iting <br /> hi <br /> 1500-2500 s!�Ptoms occur of Concentration, <br /> Ppm. n-Hc. ac vapor CVS a <br /> These effects 'pane irritates concePerations depression. <br /> Skin eo primarily be Ren after exposure goes and ranging f:om <br /> ncact an ex mucous membranes <br /> causes fat f 880 PPM far 15 +nes. <br /> Chronic removal and cutaneous minuces. <br /> The exposure to n-hexane v irricarian• <br /> Chronic <br /> clinical sign of vapors <br /> Che roes neural P causes peripheral <br /> impairmenrnd fingers. damage is a neuropathy. <br /> muscular in the Progression leads c feeling of numbness <br /> scretehi distal portions of the efurther sY�ecrical sensory weakness develo n8 reflexes, xtremiries a to <br /> Poral ps• Chiefly Ultimacely, s nd loss of <br /> �+alkingls de•:e lops with Y in the distal ymmetrical <br /> • This may varYing degrees Portion of the muscular <br /> Poivneuro include extremities• <br /> pathy), muscularatrophy <br /> Impaired <br /> grasping <br /> parallels the The development: atro p $ and <br /> cases seve Pmenc of electrophy,PhY (sensor; <br /> nerve conducricy of the clinical ialo mucor <br /> involve civity is neur Pic cure. In ogelcal changes <br /> �Iithin bent 0 also obse ralized, most severe <br /> co i0 r"ed• After In some cases. cranial new <br /> • }ears in serious oaths in mild to exposure <br /> moderate Ceases• recov e <br /> has nor oases, The thresh cases, erY begins <br /> been firmly established ld leve but may cake u° CO 3 <br /> PeaPle exPased to reprep but symptoms which neuro occurs <br /> months. crations have PathY <br /> ranging from l0 been observed in <br /> to 200 pPm -or 9,12In animals, <br /> 'apor lavcis of 1sxgns of narcosis <br /> " COncentrae' 000 pPm for are seen after <br /> oral LD ions between 4 iruceS. Beach mice are exposed to <br /> m' , <br /> so is rs ed �3 $00 and 52.000 pPm afte is-119 l' -OcmInucu ed a <br /> ., .. Young adult rats, as �., mL/kg far day-old r <br /> and ',g mL,kg for <br /> signs otg`term inhalation <br /> neurota experiments <br /> PPM for 24 weeks -rh appear after in rats suggest: <br /> they are su <br /> animals maY be This higher chr exposed chat <br /> eveiseofirst <br /> 2•hexanol due .o differe eSh°ld t° induce f 200 <br /> is the chief aces neurocexicic <br /> metabolite in Ln metabolism• Y is <br /> animals. while 2,5, Specifically, <br /> hexanedione <br />