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X. <br /> �V' '- -.• - .vier=.Nn- r- - %..., y .•+ n. �¢ ti'1,s "` +c g"'+ ""`" . .. <br /> 66-25 <br /> ZIEL OILS <br /> ion <br /> which is neurotoxic. predominates in man. eausod=caxona B <br /> alswelling and <br /> of a solvent containing 35.23 n-hexane werapplication <br /> seen. Dosage <br /> yelin degeneration ire chicks. Vo clinical signs o£ 0.5 <br /> was 1 g/kg/day for 64 da. in rabbits, topical <br /> ai.i for up to 10 days caused redness, irritation and scab formation. <br /> ;i-hexane is neither carcinogenic or ter°`cogen}c- One vivo sic in <br /> rats that inhaled 150 ppm for 5 days found an increased number of <br /> chromosome aberrations in the bone marrow cells. No studies on <br /> • mutagenicity, •reprodur-cive toxicity ., carcinogenicity in man were <br /> found (12.1930.1935). <br /> Octane <br /> be more <br /> its lower <br /> By the oral route, octane may Soxi C mcaan ca se rapid <br /> homologues. If it is a-piraced into the alung <br /> gsis and sphyxia- The <br /> death due to cardiac arrest, respiratory P y <br /> narcotic potency of octane is approximately that of heptane but it docs <br /> not exhibit the CSS effects seen with hexane or heptane. <br /> In humans. the only reported effects are"bliscering and burning <br /> ' due to prolonged skin contact. <br /> In animals. octane is a mucous membrane irritant. At high <br /> �•.•. expected that severe <br /> concentrations, it causes narcosis. It is <br /> exposure in humans will produce the same effe arrest hafter 4 miristes <br /> vapor levels of 32.000 ppm suffered respiratorym for 185 minutes caused a deetaased <br /> of exposure. Exposure to 12.840 pp. <br /> respiratory rate. followed by death within '(12,&6.1938).narcois was <br /> 2 <br /> seen after 48 minutes of exposure to 5350 pF <br /> �_. Dodecane <br /> Dodecane is not highly toxic. The lowest toxic dose for mice is <br /> weeks. Dodecane is a <br /> 11 o/kg +hen administered percucaneoualy for 2 gene. It decreased the <br /> potentiator of skin twaorigenesis by benao(a)p f 10 Dodecane and <br /> effective: threshold dose by a faceor with <br /> phenyldodecane applied topically to the progeny a£ rats treated <br /> ! <br /> benzo(a)pyrene. r_hrysene or benzo(b)triphenylene on the seventeenth day <br /> ,z benzo(a)py No additional information <br /> of gestation produced turrirs in offspring. <br /> is available (12.1937) . <br /> isopent�ne <br /> y include exhilaration. <br /> Isopencane is a Ci7S depressant. Effects ma <br /> diz=iness, headache, loss of appetite• nausea, confusion. inability to <br /> n4 <br /> headache, <br /> taste of gasoline and in extreme. cases, loss <br /> do fine work, a p m appears <br /> to have o <br /> of consciousness. inhalation of up to 500 pp PP <br /> i -Very high" vappr wncencraciors are irritating and <br /> effect on humans. g rill drY <br /> �- the skin and ever. Repeated o: prolonged skin contacte.LC <br /> defat skin resulting t1 irritation ani( dermatitis. Ch sa <br /> mouse is estimated co be 1000 mg/l. (12) . <br /> tfn <br /> y <br /> 6/87 <br /> Y <br />