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• r' t7. :SMr .,yR'fGn ME •e+ - <br /> F' <br /> i <br /> :UM 017K <br /> os-?{ <br /> ''O�,� (2,3,4-tr::etapipeata:ej <br /> aspirated P1be zso-octes are aoderateiv toxic by tha oral route. I= <br /> acan <br /> o the lungs of .rats. -...s' ey will cause ouimoaa__ lesions, <br /> 'nen injected -a=zmuscularij -'=to =r,bbi. �3 <br /> haaorxha e, nd.cc�a, r _ a-ocLaae produced <br /> 3 i:zearstl.�al pnes"nnitis, abscess Parma:i�yn, <br /> th"-Ombcsis ani. fibrosis- inhalacic-a as 15,000 nprl ecused reorMazi pry <br /> arzest in mice and 5 =inures exoasurc to 1000 ppm was highly irritating <br /> (1937) <br /> vP`is= 9�.CTSL3 e <br /> :Iechylcgclopeutaue raseubims cyelopencane is its <br /> Cycicpoassae is a CNS depressant. Humans can tolerate 10.15 toxi.eity. <br /> mica, 38 ppm causes loss of raflezes, ppm- In <br /> ' that no safe nnreosis snd ae,th d�custr5iting <br /> ty margin exists. 'iarhylcyclonenr_=e also exaibirz no <br /> sa=ecy margin between the onset or —ax'cosis and death, 4nen appliad to <br /> guinea nig skia. eyclooencane produced dryness and slight erytheza, <br /> - Methylcyclopentane would be expected to have the same efaect (Ly, <br /> `fer�vlc clohexane <br /> No systemic poisonings by methyleyclohem=0 save been reported in <br /> aan- At high vapor concenr..rarions it causes narcosis in anima <br /> ls is expected that it would prori•.2ce the same affect in humans.and ft <br /> no-effect level is about 300 m inThe <br /> Rabbits did not survive 70 minutes of ezvosur�o 15. ppm p rabbits. <br /> was preceded by conjunctival congestion, d s pea 15'227 ppm- Dta� <br /> and rapid narcosis. 6 y p • severe convu.lsiotu <br /> There were no signs of intoxication is rabbits <br /> e:;posed to 2880 ppm for a total of 90 hours, but slight cellular injury <br /> was observed in the liver and lddmevs. In concentrations caused primates, lethal <br /> mucous secretion, lacri=ation, <br /> labored breathing and diasalivation, <br /> m-hea, <br /> In chronic inhalation studies, exposure to 2000 ppm, 6 hours per <br /> ' ` Y• 5 days per week for 2 years oroduced. no -,Laors in _yts. <br /> namscers or dogs. The onlysi mine, <br /> changes in =ale rats. gruzzeaaL toxic efrect found sass renal <br /> :'hese included renal tubular dilation, <br /> hyperplasia and cedullary mineralization. p3pillary <br /> Dermal anp.licatiea er the 1igs;ic produced local ____ration. <br /> thickening anti ulceration (12,�6,Ss 17,1935). <br /> Crc�ahexzne <br /> Cyclohexane is a CNS dearessant of low tai.ici;.. Sy�tors o= <br /> ache exposure are excz�e=ent, lass of eauiiibr_'s�, stupor ,;na coma. <br /> 3crely, death results due cc resniratary =_ilure. The anesthesia which <br /> is induced is weak and of brief du.rarion but Hare potent -than that <br /> caused by hexane. Me oral Ilio in rabbits :an¢es =ram - - to 6.0 <br /> 47ithin 1.5 Fours the animals e chibi tad revere diarrhea, <br /> jici2suread vascular daaaage and callapse_ Oeeererat•-:e lesions Vere <br /> _, 6/87 <br />