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OIF,S �o-sal <br /> Methemoglobinemia (a loss of the oxygen car}•izg canaci'tf of the <br /> blood), _s r-he vain toxic of r <br /> feet of ritzit4 and strafe ingesz_on. <br /> �;:;p svzrs,=ams S.zcluda heap+=�%+e, ^at: tsn, :apses►. rooizi g, chest <br /> pain and cyanosis. with increasing tletnemoglobin concent*at:ons. mare <br /> mav be wees]=ess. dizziness. ineoordinacan_ <br /> joist pais a;t¢ »sscular <br /> - tremors (200,480). <br /> Various :+-nitroso darivativas have caused =lignant �amorz is <br /> various organ systems in laboratt'rp :L12=15. Generally, as the <br /> oolecule increases is size, carciskogenic activity dacre:sas (12). <br /> =xpasure to these compounds shouid bo avose..;d. 48Cia1Z ir-:er=ticfl OU <br /> 2 nitroso compounds - N-nitsosadiscthylanine and N-nit.-osodiphenylamine <br /> may be found in Volum* 1 of the Guide. <br /> 66.3.5 Lavels of Contemn <br /> There arc no cricaria or standards for .sel oils. OSKk (298) has <br /> sec a zine-weighted-average exposure Bele for karesene at .00 opm. <br /> 6F.3.6 Hazard Assessment <br /> Fuel oils rhemselves do not aapear to be carcinogens but they do <br /> contain several polycyclic aromatic hydrocarbons which are carcinogens <br /> and/or cocarcinogens (2219). A fuel oil blend was highly active in <br /> both cellular assays and skin painciag studies (1919). Positive <br /> mutagenic findings vere observed in an Ames test, a mouse lymphoma <br /> assay and a rat bone maxzov shy for fuel oil number 2 (191+). Diesel <br /> fuel gave nagarive result.; in both the Ames and mouse ly'mpuoma assay <br /> but positive results in the rat bone marrow assay <br /> ` A reproductive study vich ra- exposed by inhalation at Levels ctp <br /> to 408 opm suggested no adverse effect„ <br /> Acute toxic effect; of ingested -_-:el oils zaciuded aloaeeia, <br /> dermal Irr tation and open sores in the genital area of e�poscd -sts. <br /> The oral LD,, values ranged from 5 co 17.5 g/kgy for rata (1924). <br /> Dermal studies in rabbits indicated severe dermal rri_at:,on, <br /> -eight loss, anorexia. ataxia and leeharey following a dose of 5 g/kg <br /> (1124). -uel ails are also minim%lly zo moderately trriracing to <br /> rabbit eyes (1924). N chronic animal data were round. <br /> In humans. CIS depression is the e':iiei systemic reaction `.o fuel <br /> r oils (17). Ingestion Crf less Chan �i ounce has peen fatal (17). Dermal <br /> aha inhalation exposures to diesel =uel s=ave :.duced epiLopatha in <br /> humans (1314,1315.1816). <br /> . ./87 <br />