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- ! <br /> A[3'I'OMp= GASOi-T"E � <br /> r 65-29 <br /> caused by hexane. The oral LDLs is rabbits ranges from 5.5 to 6.4 <br /> I g/kg WLthia 1.5 hours the rst+i.,�i <br /> --��.. exhibited severe diarrhea. <br /> widespread vascular damage and collapse. Dageuerative lesions were 7 <br /> seen in .the he&=, lung. Liver. kidnev and brain. A one-scour vapor <br /> exposure ca 26,752 ppm caused rapid narcosis and tremor and was lethal <br /> to all exposed rabbits. Ia mica, concentrations causing -narcosis vary <br /> from: 14,600 to 122,000 ppm. <br /> Cyclohemane is nominally absorbed through the skin although <br /> massive applications (>1S0.2 g/kg) to rabbit skin resulrad in <br /> microscapic changes is the liver and kidneys and caused the death of <br /> All animals. <br /> The danger o£ chronic ning y slight because this <br /> long Pomo is relatively <br /> compound is almost complately eliminated from the body. No toxic <br /> changes were seen in rabbits exposed to vapor levels of 434 ppm, 6 <br /> hours daily for 50 exposures. but some microscopic changes were seen in <br /> the ;liver and kidneys when the exposure was to 786 ppm for this same <br /> f period. <br /> i <br /> f In man, no systemic y poisonings by cyclohexane have been reported. <br /> A vapor Level of 300 ppm is somewhat irritating to the eyes and mucous <br /> I E membranes. It has been reported' that cyclohexane may potentiate, cha <br /> toxic effects of TOCP but no additional details of this interaction are <br /> available (12,17,46,54,1937) . <br /> Benzene <br /> l it Ths primary effects of benzene inhalation and iagescion ars on the <br /> ► . cantrai nervous system (54) . Benzene is carcinogenic in both anima" <br /> and <br /> nima - <br /> and man. Sevaral reports have established a relationship bameen <br /> benzene exposure and leukemia_ For more information. refer to Chapter <br /> 18 of the Inszallatton Restoration Program Toxicology Guide, Volume L. <br /> TolMeTte <br /> r <br /> Toluene is a CUS depressant p eat v tth a low toxicity. For more <br /> information. refer to Chapter 19 of the Installation Restoration <br /> f Program Toxicology Guide, Volume L. f <br /> '-• - Kylenes <br /> j <br /> '? Acute exposure to high concentrations of xylene vapors may cause <br /> CHS depression. Both the Li d and the vapor are irrttat to the <br /> � ap � i <br /> eyes, mucous membranes and skis (46). The National Toxicology Program f <br /> recently reported that there was no evidence of carcinogenicity of <br /> mixed xylanes in either mice or rats given daily doses ranging from 250 j <br /> to 1000 mg/kg by gavage for 2 years (1939) . <br /> For more information. refer to Chapter 21 of the Installatiort <br /> Restoration Pro ram Toxicolo Guide. Volume L. <br /> gY <br /> {, k <br /> 6/87 <br /> E• <br /> 11 <br />