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UaMMT= GASOL= b5-33 <br /> Isopropyl alcohol has moderate narcotic properties:. Ingestion <br /> causas CNS aepression and it is expected that sustained _,.halation of <br /> high vapor coacantrations will produce rho same effect_ _t is also � <br /> tzritating CO rhe eyes and mucous membranes (2,46) . A=i oral LD., of <br /> 5860 mg/kg vas reported for the rat (47) , <br /> 65.3.4 Levels of Concern <br /> i® <br /> Ihs ACGM (3) recommends an occupational exposure Limit of 300 ppm <br /> for autcmotiva gasoline, with a shorn-term exposure Limit of 500 ppm. i <br /> No, other critaria or standards have been established with regard <br /> a <br /> to human health and safety. <br /> 65.3.5 H&zard Assessment <br /> E <br /> A °siagla study (2298) on the potential carcinogenic effects of <br /> gasoline is avaylabla. Rica and rats ware exposed by inhalation to the <br /> vapors of unleaded gasoline (baeszsne contour.. 21k). 6- hours par day. 5 k <br /> days per vaaic for two years. Exposure levels ranged from 67 to 2056 <br /> Ppm- Doss-related renal carcinomas were observed in gasoline-expoaad <br /> male rats fha w i ficaaca of the sex-specific and species-specific <br /> f <br /> �$s lhatageaicitp studies suggest iza ganotoxia effects <br /> for wnlaaded gasoline (2301.2303.2300,2304). Negative Carazogenic <br /> findings vera also reported (2228). although details are lacking. <br /> Animals scudias indicate kidney damage is P:M predosinaat toxic <br /> : effect of acuu ingestion and chronic inhalation exposure to unload" <br /> gasoline (2290,2294). puLmonaxy changes (fibrosis and sclerosis) vara <br /> also evident with inhalation expoaure (2296) . <br /> Mu"ns exposed via inhalation to 500-1000 ppm gasoline for 30 to <br /> 64 'minutas develop at=La. drowsiness and dL=I •--s; levels of <br /> 1000-3000 ppm result in irritation. headache. nausea and vomiting; <br /> exposure to greater than 5000 ppm can cause deep anesthesia within <br /> minute42. and occasionally, coma and death (2277,2284). <br /> Iagnscicu of 20 to 50 g of gasoline may produce severe intoxi- <br /> cacioa; in adults (12) . Symptoms of poisoning are similar to those <br /> noted above for inhalation exposures. <br /> 65.4 SAMPL=G AND ANALYSIS CONSIDERATIONS <br /> DeterminAcion of the presence of automotive gasoline in soil and <br />_ vacar , requires collection of a representative field sample and <br /> laboratoty analysis for the specific major components actribueed to <br /> gasoline; however, the raiativa concentrations of the constituents, and <br /> #a € <br /> 4 6/87 <br />