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r <br /> w <br /> spontaneous motor activity and reduced performance connected with <br /> disturbances of the motor coordination system; however the severity of <br /> these effects does not indicate serious toxic damage, to the CHS. The f <br /> study concluded that HTBE "does not even minimally increase the r� <br /> neurologic effects with respect to gasoline itself." The level of <br /> exposure or the species which were tested were not reported (2293) . <br /> t-Rutvt alcohol <br /> At high concentrations, c-butyl alcohol causes narcosis in animals <br /> and it is expected to cause the same effect in humans. Other than <br /> E. slight skin irritation, no effects have been reported from industrial <br /> exposure. The oral LD., in the rat is 3500 mg/kg (46) . T <br /> Ethanol <br /> Ethanol is irritating to the eyes and mucous membranes. It is F <br /> also a CNS depressant. The acute toxicity of ethanol is low for both <br /> an4miifa and man. Overexposure causes ataxia, incoordination and <br /> drowsiness (2,46) . An oral LD., of 14 g/kg was reported for the rat i <br /> (47) . <br /> --; 1 <br /> Methanol <br /> f <br /> Methanol causes optic neuropathy and metabolic acidosis. <br /> Poisoning has occurred primarily from ingestion of adulterated <br /> alcoholic beverages. After ingestion there is a latency period of 18 <br /> to 48 hours after which exposed individuals develop symptoms of nausea, <br /> abdominal pain, headache and shortness of breath. Visual symptoms <br /> range from blurred or double vision to changes in color perception, <br /> constricted visual fields and complete blindness. Other symptoms of <br /> intoxication include dizziness, behavioral disturbances. neuritis and <br /> acidosis. The degree of acidosis has been found to parallel the <br /> severity of the poisoning. Evidence suggests that exposure to vapor <br /> concentrations of 200-375 ppm causes recurrent headaches and visual <br /> disturbances are seen at vapor levels of 1200-8300 ppm (2.46) . An oral <br /> LD., of 13 g/kg was reported in the rat (47) . <br /> Tri-Ortho-cresvi phosphate (TOCP) <br /> TOCP affects the spinal cord and peripheral nervous system. <br /> Symptoms of acute exposure, including nausea, vomiting. diarrhea and <br /> abdominal pain, are followed by a latent period of 3 to 30 days. At -� <br /> this time. there is muscle soreness, numbness of fingers. calf muscles <br /> and toes which progresses to foot and wrist drop. These effects are <br /> manifested after ingestion, inhalation or dermal absorption (54) . An <br /> oral LDSo of 1160 mg/kg has been reported in the rat (47) . More <br /> information on TOCP can be found in Chapter 49 of the Installation <br /> Restoration Program Toxicology Guide. Volume 2. <br /> 6/87 L T, <br />