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duration of e:cn_ osure. Dose-related _affects is neurological testing <br /> Ladi=ca that the uncambusced diesel vapors may also act as a <br /> -eurodeoressant (2334) . Y <br /> Ia acute dermal studies conducted i:t rabbits. number 6 heave fuel <br /> Oil (APT gravity 5.2/1.23 sulfurs induced significant signs of toxicicr <br /> ae 5 9/kg. It caused severe dermal irr#.tarfon. weight loss, anorexia. k <br /> atarcia and lethargy. :Eortality was 37.5%. Necropsy revealed acute <br /> caxic hepatitis. gastrointestinal Lrriration and congested lungs. , <br /> Other grades of number 6 and number 2 oils as wellas diesel oil <br /> produced mild to moderatE dermal irritation but no Syszamic signs of <br /> toxicity <br /> Ia the subacute dermal study. doses ranging from L to LO <br /> were applied to rabbits clipped free of hair. The area remained <br /> bandaged for 24 hours AC which time the patches were removed and a new <br /> dose applied. This continued Ear 5 consecutive days followed by a 2 <br /> day rest period and a reeear appiica=ion for 5 consecuti•re days. In <br /> chis test. the number 6 fuel oil (API gravity 5.1/1.Z3 sulfur) nroaucad <br /> .he greatest degree of toxicity at the lowest dose (75% mortality ac T' <br /> 2.5 ml/kg) , Clinical signs includedsevere Leight Loss, anorexia and <br /> signs of dermal irritation. Cross enteritineer'opsy revealed hemorrhagic <br /> ar degeneration. In all casesand congested, mottled Livers with multifocal necrosis <br /> Sas <br /> and c , <br /> and centrilobull ar vacuol <br /> Oils caused inflammation. the number 6 <br /> the congestion and edema. dermal necrosis. <br /> acanrhosis and parakeracosxs. diver necrosis and degeneration were <br /> also seen but the severity was not as great as that. with 5.1/1.21 <br /> sulfur. AL1 3 number 2 oils caused weight Loss. anorexia and various <br /> degrees of dermal irritation. AC a dose of 10 ml/kg. mortality ranged <br /> from 75 to L00%. Crass <br /> renal and hepatic necropsy lesions at all dosage levels included <br /> congestion. At the i0 m <br /> keaatic necrosis vas observed (1924) . <br /> level, multifocal <br /> (1924) , <br /> In primary dermal irritation tests, the number oils were <br /> i <br /> �aoderacely rritating while crit number 6 oils were minimally co <br /> included <br /> slighted irritating. Diesel fuel vas extremely irritating. .Signs _ <br /> erythema and edema with blistering and open sores. the <br /> cost was conducted by applying 0.5 imL. of undiluted material to abraded <br /> rabbit skin. The test was then covered for 24 hours at which point the <br /> bandage was removee and .he animals scored <br /> Cecnnique (1924) . according Co the Draize <br /> The number 6 oils were minimally to moderately irritating when 0. 1 <br /> eL. las applied to rabbit eves. These materials producea con]unccival ^� <br /> redness. swelling and discharge. Few corneal opacities -ere produced <br /> but eyes returned co normal within 72 hours. Diesel fuel was F <br /> conmiidl-irricacing irritacdnnumber 2 oils ranged from practically non- irritating <br /> Y $ (1924) , Yr <br /> 6/87 ., <br />