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EL OILS 66-25 <br /> �-;nich is neurotoxic. predominztas in_ can. Chronic Capital application <br /> of a solvent containing 35.29 n-hexane caused axonal sweLliag and <br /> rsrelin degeneration in chicks. :?oc'_��=c_: signs Caere seen. Dosage <br /> wu L <br /> 9/kg/day for 64 days_ In rabbits. topical applicarion of 0.5 <br /> qday for up to 10 days caused redness, irritation and scab £ormatian. <br /> :i-hexane is neither carcinogenic or teratogenic. One in 21vo scudy in <br /> rats that inhaled 150 ppm for 5 days found an increased number of <br /> chromosome aberrations in the bone marrow cells. No studies on <br /> anitagenicity, reproductive toxicity or carcinogenicity in man were <br /> founa (12.1930, 1935) . <br /> 0 to e <br /> 8y the oral route, octane may be more toxic than its lover <br /> homologues. If is is aspirated into the lungs, iz may cause rapid <br /> death dua co cardiac arrest, respiracorr paralysis and asphyxia. The <br /> narcotic potency of octane is approximately that of heprane but is does <br /> noc exhibit the CVS effects seen with hexane or heocane. `~ <br /> In humans. the aniv Cavorted effects are blistering and burninz <br /> due to prolonged skin: contact. - <br /> In animals, octane is a mucous membrane irritant. AC high <br /> concentrations. Lt causes narcosis. IC is expected that severe <br /> exposure in humans will produce the same effects. dice exposed to <br /> vapor Levels of 22.000 ppm suffered respiratory arrest after 4 minutes <br /> Of exposure. Exposure to 12,840 ppm for 185 minutes caused a decreased <br /> respiratory_ race, for <br /> by death within 24 hours. No narcosis was <br /> seen after 4a minutes of exposure to 5350 ppm (12.46,1938) . <br /> Dodecane <br /> Dodecane is nor- highly toxic, The Lowest toxic dose for mice is <br /> L1 5/kg when adminiseerea percutaneously Ear 22 weeks. Dodecane is a <br /> potentiator of skin tumorigenesis bv_ benzo(a)pyrene. IC decreased the �. <br /> effective threshold dose by a factor of L0. Dodecane and <br /> phenvldodecane app lied capitally to the progeny of rats created with <br /> benzo(a)pyrene, chrysene or benzo(b)CriphenvLene on the seventeenth dav <br /> of gestation produced cusaors in offspring. No additional information <br /> is available ( 12, 1937) _ <br /> Tsoornrcne .�. <br /> Isoneneane is a CNS depressant. Effects may include exhilaration. <br /> dizziness, headache . Loss Of eppetice. nausea. contusion. inability to " <br /> do Eine work, a persistent taste of gasoline and in extreme cases, loss <br /> Of consciousness . Inhalation of up to 500 ppm appears to have no <br /> effect on humans. 'very high- vapor concentrations are irritating to <br /> the skin and eves. Repeated or prolonged skin contact -,ill dry and ._ <br /> defac skin resulting in irritation and dermatit-is fie LC=Q in the <br /> mouse is estimated to be LOGO mg/L, (12) <br /> 6/87 <br />