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ll. <br /> i' <br /> �� 1S0-OCz�iwt ate mo <br /> aspizarzd der3ra.ly _.pate- i f <br /> iZ=n rs' a Ltims�s o= rz�t. :av gill causa -JUA=onazT _esicai. <br /> ,.nen in3 ecrad <br /> ede,Mai� inch C..bhirs. iso-ocraaa producad <br /> iztterszd...al pnetCmCzLLJ .-i s. abscess <br /> C3soahosis and fib=osis. Inhalacloa of 16.000 -ar�ariaa. <br /> uresc is mica and 5 mzat:r.es exaosssrc =a 1.000 gG-tLsad resnitarerf i <br /> {1937} . E 1 higaiy ixr;�r � <br /> 1 <br /> =� FlC7ci'penrsae rras�ales cyclopea= = i= its :amici <br /> Cyclopenrxaa is a CNS dapre==r_ Humes cab rolerara 10-15 rF- <br /> • 3that FP= C— as loss of reflexes_ na= 031 t and deach dan== <br /> sa£tep rgia exists_ "�thplcpclaaeat�c also exnibiir <br /> safttp margo bers*aea the onset of nsx=xsis and daarh. when applied co <br /> ao <br /> �sinea big skin: cycloaenC=a produced dryness a3ld sliga= ar�ttemz. <br /> Htthvlcyc3aaeatae �.►ouid be expecred to h� raa same effacz (Ii). <br /> it Het}v}cve o t a e <br /> No�s s <br /> a y te$ic aoisoniags by mechylcyclohimame nave been repor=ad j= <br /> At high -Tactor concea=rzcloas lZ CSLLSes T�.TCOs1S la �*+� <br /> + is expecrad that t= vau.td ana it <br /> S € produce :he same effacz in h•==-as_ the <br /> no-effect level is about 300 ppm i.,= primates and 1200 ppm in rabbirh <br /> Rabbirs 'did hoz survive 70 mirn.rs� <br /> s. <br /> Of emos=e to 15.227 ppm_ Dear <br /> vas preceded by coa�uacrivai congestloa. dyspnea. severe convmLsious <br /> a=td rapid narcosis_ There were no sigmas of fatoxi.cacioa in rabbits <br /> 1 exposed tD 2880 peat far, a total of 90 hos=. bur slight cellula i=j=y <br /> 1 Was observed in Che Zi4er =Uj 1a.dnevs_ In grimaces. lethal <br /> c eenm.:rians caused cocoas secretion, lacy-i= ion, salivation. <br /> laboren ',breathing and dicer=mea_ <br /> Ice. cizroaic inbslaczoa studies, exoosure to 2000 ppm. o hours par <br /> may. 3 daps per veeic for 2 years grodueed no Mors im ,_:=.5. rzice. <br /> hamsters or dogs. The only sigaizicsar Comic effect found _as renzL <br /> *' chanSeS- is :bale 'ram- Wiese included renal ctzbular dila=ion_ _aaiilarr <br /> hyperaI-Iis and m.--d Lllary minerali===ion_ <br /> +Onzsal aaPlicacxon o - <br /> t the 1_1�12.ZG produced local <br /> I ickening and ulcera=ion c12.:,b.!!,, 17.1935) , ----- <br /> L Cee!oherarne <br /> ' Cyclohexane :.s C � <br /> a ::5 depressant of lcw caxici�:. Sti�atcros o� <br /> ecus ex,eosuze are exei=c_ent, loss of equilibrium, scuaor amr- coma. <br /> Rr_rely, death resulrz dupe 'co respiratatp failure_ The aaesrncstz waica <br /> is induced is weak - <br /> and a: brief ds:raarl but =ore�.. gocewr =baa that <br /> caused bT hexane- The oral. IZIa in r=hbi- s rouges =,am : . is 6-0 <br /> :s ?_� }'-ours the ani—zis exhibited severe c=arriea. <br /> •-icesuread aama£e <br /> and collaase_ Deger_erac_-,a -asic were <br /> F t <br /> A 67 f <br /> i a° <br />