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i 0I= 66-29 <br /> eist[firacrn. <br /> Anthracene asserts phototaxis and paotoallergia ac=ion on the <br /> h=aa skin. It- is carciaogeniczUy inaccfva (12) . Variaus <br /> =ra9aaiei=T studies have ,produced negative responses (2315) . The r <br /> lowest toxic oral dare is the rat is 20 g/kg (47) . <br /> 66,3.4 Toxicology of Fuel oil Additives <br /> The toxicity of selected fuel oil additives is Outlined below. <br /> Hsagaaeze affects the CHS. Incaxication occurs mostly in tha <br /> '*hronic farm know" az mangaaism which is similar ca Parkirtsonism. <br /> Vsually manganism occurs after 1.2 years exposure co manganese oxfdas <br /> although it may develop after only a few months. Initial symptoms <br /> include headache, asrx►enia (loss of strength and energy) . restless y <br /> sleep and personality change, This is followed by an intermediate <br /> Phase with visual halluciAatians, double vision. impaired hearing <br /> unconcroLlable impulses. mensal confusion and euphoria. In advanced <br /> stages. tha patient experiences excessive salivation, muscle vealateas. <br /> Sair.. In, man e rigidity. tremor of the upper extremities and head, and impaired <br /> gait. ganism with neurologic symptoms. the course is frequently <br /> progressive although some cases are stationary, and others recover <br /> Inhalation of high concentrations of manganese oxide causes metal <br /> Fume fever - a 24.48 hour illness characterized by chills, (aver. <br /> aching muscles, dry mouth and throat. and headache (46) . <br /> Magnesium oscide -� <br /> Magnesium oxide fumes are irritating to the eves and nose. rt <br /> also causes mesal fume fever which is a 24-48 hour influenza-type <br /> illness (46) . <br /> Akuainvm Oxide <br /> Aluminum oxide is a nuisance dust which has Littte adverse effect <br /> on she lungs at low exposure levels. Excessxve concentracions may <br /> cause deposits in the eves, ears and nazak passages or may cause mild <br /> injury to the skin and csucouz membranes (46) . <br /> [?eros s <br /> Ln general, peroxides are strong oxidising agents capable of skin <br /> irr:zation. burns or eye damage (200) . <br /> 6/87 <br />