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{� TU-Im nus <br /> k <br /> LtLrgl.beaseae is rs -� . ' �- i <br /> =P.sn P �t.L4 as :L;- c ra chm ski=t. eye= and t=ftr ! <br /> . ip =4ic=. 5ysremc ausorP=-= causes LL.'S deorrssioz (4.b) <br /> r. � J <br /> For mote is%zarmar%On. rrfer -o Chzares 20 of the iaarayLw- <br /> Progt�.Tozicoiogy Guide. 7ai1T� 1_ <br /> the ,�BRZBaQS CC= 1.Z 3 Isomer1G ;fox=- <br /> The 1,3,3-Lsamer <br /> (me:it71wm) and Lha- L.2.4-isamex (pseudocumene) are taxicala <br /> Sir-' Hi$h vapor coacesirzzrinas Bically <br /> � '�' depressiaa CSM <br /> is sir. (3000.9000 ppm) csxse <br /> Loss of rar3exes vas Sean is mien exposed to k <br /> 8130-3I40 plmt of tha 1.2.4-isomer or 8130 ppm of :he 1.3.5-Lsomar. <br /> Hats e�mosad ra 1700 ppm of as iSomer►M mixc= for <br /> -0-21 dsss <br /> hsdadveme, effmc= or fariit�rs. zso <br /> ° 1ha; fate' iattaParitaaeil dare of tt= 3..2.4-isomer for :.ha <br /> Pig is 1'_788 g/kg. visile the ural dose of taxa 1..3.5-isomer b4 the a <br /> mate is g/Lg far Lha raz. For rhe 1,2.3-isormer. o� oral I�I.Q•ai <br /> 3000 mg/kg hax been reported is rlae ras. Trimer3sg3.b—eae liquid ix a <br /> PzI=x3r skin irrltaut. Deposir as iarn �e lungs causes pneumonitis a= <br /> the sire of warner:. <br /> ?he aaiy report of homan exposrsra described symptoms of <br /> L�faa, acv, a=mac Brom ims. hypochromic Searle <br /> and cb=Bes in „t3xe coagulabiliL7 of the blood. Vapor concert--ratfeas <br /> 1 ranged from LO-60 ppm- Exposure was to a m;m=e con=inin3 30% of the <br /> 1.3.5-isomer and 50% of :he L,2.4-isomer (2.1Z). <br /> " :tethvtnanhrhalere <br /> { ' <br /> lha ortly adverse of:!ar-= of me-chvlaaph;.haleae reporrad _a man axe <br /> j - skirt irrttaLion and phoroser=iti=apart (17) . Oral LasQ values of 1840 ! <br /> { _m3/k6 azsd Zb30 m 1. ,. <br /> . �/kg hire been reaorLed for mectr7ir.aahr�-este arui <br /> Z-sIIethp� httzalene, resrsecr-I elv. is the xac (47). i <br /> Ianhtlta l one <br /> lstgezrion or prolonged iahaI =jcn oz malt-�halame prod_ces =use&. <br /> vamiriag and disarzeara=inn. i= is i =:L=zing ca cha skin and eves and <br /> prolonged v=par e=osuza has led to c-ztzracr. formation is rs rt7). <br /> HemolyLie aT,pmi s is the cosc severe e=fecc associated —lta nz-ahr-hz-1cae <br /> exposuxc. bun zh" effect is seers <br /> preaamirtautly in individtsais viLh an <br /> anzyme deficiency (54) . <br /> �e <br /> For =ore in3Eor=atzan. refer ;0 Chanter 32 of .he =a:�.11ician <br /> Rescaratinm Toxicology Coude. Volu=e l_ <br /> �w 4 <br /> i <br /> S <br /> 9I i <br /> 5/87 <br />