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The exposure parameters used to develop the onsite indoor worker exposure scenarios at the site are conservative estimates of the true exposures Although indoor workers are present at the site, the assumed duration of exposure is likely to be much greater than the true duration For instance, an indoor onsite ' worker is assumed to be indoors 8-hours per day, 250-days per year, for 25 years In reality, based on Department of Labor statistics regarding average job tenure nationwide, this type of worker would be expected to remain in his/her fob less than 10 years Likewise, the onsite outdoor worker is assumed to have the same exposure frequency and duration as the indoor worker In reality, based on weather conditions alone, a worker will not be outdoors 250-days per year For the same reasons documented above, a worker would not be expected to remain in his/her fob for a 25-year duration Consequently, the outdoor worker scenario also overestimates the true risk/hazard, while umderestumating action levels associated with site-related COPC emissions ' 3.3.5 Toxseologieal Endpoints Several aspects of the toxicological data employed in the ASTM RBCA process contain a high degree of uncertainty that affect estimation of risk and delineation of RBSLs These uncertainties arise in two primary areas First, slope factors used in this assessment correspond to ' the 95%UCL on the low-dose portion of the chemical's dose-response curve, as extrapolated from high- dose human or animal response data using the EPA linearized multistage model (LMS) This assumption means actual risks are likely to be lower than the risk estimates calculated in this assessment Second, results of animal studies are often used to predict the potential human health effects of a chemical Extrapolation of toxicological data from animal tests is one of the largest sources of uncertainty in the human health risk evaluation process There may be important, but unidentified differences in uptake, metabolism, distribution, and elimination of chemicals between a test species and humans Animal studies are usually conducted under high-dose conditions, whereas humans are rarely exposed to such high doses ' The dose level itself may be responsible for the observed carcinogenic effects Also, animal lifetimes tend to be less than two years, while assumed human life expectancy is 70 years ' 3.3.6 Interpretation of Target Risk Levels: The excess lifetime cancer risk used to evaluate carcinogenic compounds is often misunderstood For example, a risk level of one-in-one million(l x 10-6) associated with exposure to a particular chemical is often misconstrued as an expectation that one out of ' one mullion people exposed to the chemical will be stricken with cancer In actuality the carcinogenic risk is not an actual risk, but rather a mathematical risk based on conservative scientific assumptions used in the risk assessment process The Food and Drug Administration(FDA) uses this conservative estimate to ' ensure that the risk is not understated Uncertainties from the various sources discussed above are additive, hence, the overall effect of using conservative assumptions in each step of the risk assessment process results in significant overestimation of potential risks/hazards, and an underestimation of action levels Accordingly, comparison of COPC concentrations with applicable RBSLs must be viewed with an understanding of the uncertainty and conservatism involved, and how these effect risk estimations Because of the high degree of conservatism associated with the RBCA process, findings of insignificant risk (high RBSLs) may reflect conditions close to reality, however, findings of measurable risk (low RBSLs)may reflect conditions that result from the conservative nature of the evaluation 14 i{