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?XTOXNET PIP- CAPTAN Page 1 of EXTOXNET Extension Toxicology Network Pesticide Information Profiles Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the Jniversity of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology, Michigan ;tate University. Major support and funding was provided by the USDA/Extension Service/National Agricultural 'esticide Impact Assessment Program. ?XTOXNET primary files maintained and archived at Oregon State University tevised June 1996 Captan grade and Other Names: Trade names for captan include Agrox, Captal, Captec, Captol, Captonex, Clomitane, Aerpan, Meteoro, Orthocide, Phytocape, Sepicap, Sorene, and Vancide 89. Captan may be found in formulations with a vide range of other pesticides. tegulatory Status: Captan is a General Use Pesticide(GUP), though most uses of the compound on food crops vere cancelled in the U.S. in 1989. It is categorized as toxicity class IV -practically nontoxic. However, it bears the ;ignal Words DANGER or CAUTION if packaged in concentrated form because it can be irritating to the skin and eyes :heroical Class: phthalimide ntroduction: Captan is a nonsystemic phthalimide fungicide used to control diseases of many fruit, ornamental, and ,egetable crops. It improves fruit finish by giving it a healthy, bright colored appearance. It is used in agricultural rroduction as well as by the home gardener. A major use of captan is in apple production. °onmulation: Not Available toxicological Effects: . Acute toxicity: The rat oral LD50 for captan ranges from 8400 to 15,000 mg/kg, indicating very low acute toxicit [15]. The mouse LD50 is 7000 mg/kg. Sheep showed no effect at doses of 200 mg/kg,but experienced deaths at 250 mg/kg. The inhalation LC50 (2-hour) in mice is 5.0 mg/L [8]. Rabbits showed little or no skin sensitization to captan, while guinea pigs were moderately sensitive [6]. Workers exposed to high concentrations of captan in air mg/m3) experienced eye irritation including burning, itching, and tearing. Skin irritation also occurred in some cases [6]. . Chronic toxicity: Rats fed up to 750 mg/kg/day of Orthocide for 4 weeks had decreased food intake and body weights [6].No deaths occurred in pigs given as much as 420 to 4000 mg/kg/day in the diet for 12 to 25 weeks, however, cattle given six doses of 250 mg/kg experienced varied toxic effects, including death [6]. ittp://extoxnet.orst.edu/pips/captan.htm 7/2/201