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3XTOXNET PIP - GLYPHOSATE Page 1 o1 EXTOXNET Extension Toxicology Network Pesticide Information Profiles k Pesticide Information Project of Cooperative Extension Offices of Cornell University, Oregon State University, the Jniversity of Idaho, and the University of California at Davis and the Institute for Environmental Toxicology,Michigan ;tate University. Major support and funding was provided by the USDA/Extension Service/National Agricultural 'esticide Impact Assessment Program. ?XTOXNET primary files maintained and archived at Oregon State University tevised June 1996 Glyphosate grade and Other Names: Trade names for products containing glyphosate include Gallup, Landmaster, 'ondmaster, Ranger, Roundup, Rodeo, and Touchdown. It may be used in formulations with other herbicides. Regulatory Status: Glyphosate acid and its salts are moderately toxic compounds in EPA toxicity class II. Labels or products containing these compounds must bear the Signal Word WARNING. Glyphosate is a General Use Pesticid( GUP). Chemical Class: Not Available Introduction: Glyphosate is a broad-spectrum, nonselective systemic herbicide used for control of annual and )erennial plants including grasses, sedges, broad-leaved weeds, and woody plants. It can be used on non-cropland as we is on a great variety of crops. Glyphosate itself is an acid,but it is commonly used in salt form, most commonly the sopropylamine salt. It may also be available in acidic or trimethylsulfonium salt forms. It is generally distributed as water-soluble concentrates and powders. The information presented here refers to the technical grade of the acid form of ;lyphosate, unless otherwise noted. Formulation: Glyphosate itself is an acid, but it is commonly used in salt form, most commonly the isopropylamine ;alt. It may also be available in acidic or himethylsulfonium salt forms. It is generally distributed as water-soluble ;oncentrates and powders. toxicological Effects: . Acute toxicity: Glyphosate is practically nontoxic by ingestion,with a reported acute oral LD50 of 5600 mg/kg ii the rat. The toxicities of the technical acid (glyphosate) and the formulated product(Roundup) are nearly the samf [58,96]. The oral LD50 for the trimethylsulfonium salt is reported to be approximately 750 mg/kg in rats, which indicates moderate toxicity [58]. Formulations may show moderate toxicity as well (LD50 values between 1000 mg/kg and 5000 mg/kg) [58]. Oral LD50 values for glyphosate are greater than 10,000 mg/kg in mice, rabbits, an; ttp://extoxnet.orst.edu/pips/glyphosa.htm 7/2/20