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cyanazine(Bladex)Herbicide Profile 12/84 Page 2 of 4 <br /> - Acute oral LD50 - 334 1 %g (male rats) , 156 mg/kg (female �3) <br /> (Category II) %m► �I <br /> - Acute dermal LD50 - >2,000 mg/kg (rabbits) (Category III) <br /> - Acute inhalation toxicity - LC50 >2.28 mg/kg (Category III) <br /> - Primary eye irritation - mild eye irritation (Category II) <br /> ` - Major routes of exposure: dermal, inhalation <br /> - Chronic effects <br /> - Oncogenicity: results inconclusive <br /> - Teratology: F-344 rats - increased incidence of anophthalmia and <br /> microphthalmia at 25 mg/kg/day, NOEL = 10 mg/kg/day. Increased <br /> ` incidence of diaphragmatic hernia in all treated groups. More <br /> data are required to ascertain the nature of this effect. <br /> Sprague-Dawley rats - slight decrease in maternal body weight at <br /> 30 mg/kg/day. NOEL = 3 mg/kg/day. Rabbits - maternal toxicity <br /> and fetotoxicity at 2 mg/kg/day. NOEL = 1 mg/kg/day. <br /> - Mutagenicity: data gap <br /> - Immunotoxicity: data gap <br /> Physiological and Biochemical Behavioral Characteristics <br /> Translocation: When applied to soil, cyanazine is absorbed by the <br /> .. roots and translocated to the leaves. <br /> Environmental Characteristics <br /> Absorption and leaching characteristics: Cyanazine is reversibly <br /> adsorbed to soil particles. The degree of adsorption varies with <br /> soil texture, water content, and organic matter content. Leaching <br /> rate into the soil was measured on a sandy loam soil and found to <br /> be comparable to that of atrazine. <br /> Microbial breakdown: Cyanazine is degraded in the soil primarily <br /> by microbes. <br /> Loss from photodegradation and/or volatilization: Under field <br /> conditions there is only a minimal loss of cyanazine by either <br /> photodecomposition or volatilization. <br /> Resultant average persistence: Half-life about 2 weeks under <br /> conditions favorable for plant growth. <br /> Half-life in water: unknown. <br /> Ecological Characteristics <br /> low - Hazards to birds: Data are incomplete. Preliminary data show low <br /> toxicity, suggesting minimal hazards. <br /> - Hazards to fish and aquatic invertebrates: Data are incomplete. <br /> Preliminary data show low toxicity, suggesting minimal hazards. <br /> - Potential problems with endangered species: No hazards indicated. <br /> Tr.l a To0eET—ent <br /> __________ _______ <br /> r <br /> - List of crops and tolerances (CFR 180.307) : corn, fodder - 0.2 ppm; <br /> corn, forage - 0.2 ppm; corn, fresh (Inc. sweet) (K+CWHR) - 0.05 ppm; <br /> corn, grain - 0.05 ppm; cotton, seed - 0.05 ppm; sorghum, forage - <br /> .. 0.05 ppm; sorghum, fodder - 0.05 ppm; sorghum, grain - 0.05 ppm; <br /> wheat, forage, green - 0.1 ppm; wheat, grain - 0.1 ppm; wheat, <br /> straw - 0.1 ppm. <br /> - List of food contact uses: corn, cotton (oil) , sorghum, wheat. <br /> - Results of tolerance assessment: No ADI can be set at this time. <br /> 4. SUMMARY OF REGULATORY POSITION AND RATIONALE <br /> - Use classification: Reclassified (by the Registration Standard) as a <br /> Restricted Use chemical because of teratogenic effects, and because <br /> it is found in groundwater. <br /> - Use, formulation, or geographic restrictions: Manufacturing-use <br /> products may only be formulated into end-use products intended for <br /> use as a herbicide on corn, cotton, sorghum, or fallow land, or <br /> winter wheat. <br /> - Unique label warning statements: <br /> - Use classification statements: Labels of all formulated products <br /> must bear the following statements: <br /> http://pmep.cce.comell.edu/profiles/herb-growthreg/cacodylic-cymoxaniVcyanazine/herb-prof-cyanazine.htral 10/30/2003 <br />