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cyanazine(Bladex)Herbicide Profile 12/84 Page 3 of 4 - RESTRICTED USE PESTI( Because cyanazine can leach in' groundwater, and has Smo6duced birth defects in laboratory*406mals, this product may be applied only by certified applicators or persons under their direct supervision. ; and - Cyanazine is a pesticide which can travel (seep or leach) through soil and can contaminate groundwater which may be used as drinking water. Cyanazine has been found in groundwater as a result of agricultural use. Users are advised not to apply cyanazine where the water table (groundwater) is close to the surface and where the soils are very permeable, i.e. well-drained soils such as " loamy sands. Your local agricultural agencies can provide further information on the type of soil in your area and the location of groundwater. - Precautionary statements: Labels of manufacturing-use products and end-use products (EDPs) must bear the statements: (Hazards to Humans Statements) - WARNING: May be fatal if swallowed. Harmful if inhaled or absorbed through the skin. Causes substantial but temporary eye injury. Avoid breathing dust (vapor or spray mist) . Avoid contact with skin, eyes, or clothing. Do not get in eyes or on clothing. Wear a face shield. Wash thoroughly with soap and water after handling and before eating or smoking. Remove contam- inated clothing and wash before reuse. ; and - Use of this product may be hazardous to your family's health. This product has been determined to cause birth defects in laboratory animals. Exposure of women of child-bearing age to cyanazine should be avoided. ` - Statements of practical treatment: - If on skin: Wash with plenty of soap and water. Get medical attention. - If in eyes: Flush with plenty of water. Call a physician. - If swallowed: Call a physician or Poison Control Center. Drink 1 or 2 glasses of water and induce vomiting by touching back of throat with finger. Do not induce vomiting or give anything by mouth to an unconscious person. r. - Environmental hazard statement: The following specific statements must appear on the labels of all manufacturing use products: - Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless this product is specifically identified and addressed in an NPDES permit. Do not discharge effluent containing this product to sewer systems without previously notifying the sewage treatment plant authority. For guidance, contact your State Water Board or _ Regional Office of the EPA. - The labels of EUPs intended for outdoor use must bear one of the following statements, depending on the formulation of the product: - Granular products must bear the statement: Do not apply directly to water or wetlands. In case of spills, collect for "' user or properly dispose of the granules. Do not contaminate water by cleaning of equipment or disposal of wastes. - Non-granular products must bear the statement: Do not apply rii rontl.. fry �tnr rir 01-1�»rlc T1n r�1- »t�mi»�fc motor L... cleaning of equipment or disposal of wastes. - The label of all products (except those, if any, intended solely for household use) must bear the appropriate container disposal statement, as will be given in Appendix IV-5 of the guidance package. - The required statements listed in this standard must appear on the labels of all MUPs and EUPs released for shipment after June 30, 1985. After review of data to be submitted under this standard, r.. the Agency may impose additional label requirements. Summary of risk/benefit analysis: Cyanazine produces teratogenic effects in laboratory animals. Exposure to the public through the dietary route is not sufficiently large to exceed the risk criterion in 40 CFR 162.11. Margins of safety are adequate for that route. ` However, the dermal exposure rates of mixer/loaders and applicators are comparable to levels at which effects occur in experimental animals. This triggers the risk Criterion in 40 CFR 162.11, sending cyanazine into the Special Review Process. The benefits of cyanazine are primarily from its effectiveness as a herbicide to corn, which accounts for 96% of total use. Available alternatives to cyanazine do not have as broad a spectrum of weed control. The most widely used alternative is atrazine, which may have more persistent residues and leaches through the ground at the same rate as cyanazine. On cotton (3% total use) the alternatives again do not provide as broad http://pmep.cce.comell.edu/profiles/herb-grow[hreg/cacodylic-cymoxanil/cyanazine/herb-prof-cyanazine.html 10/30/2003