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EPTC(Eptam)Herbicide Profile 10/83 Page 2 of 4 <br /> Category II <br /> - Primary dermal irritated in rabbits: mild skin irritant, *00 <br /> Toxicity Category IV <br /> - Chronic toxicology studies on EPTC are as follows: <br /> - In a 54-week feeding study of EPTC in rats: the NOEL was 20 <br /> ` mg/kg/day; the LEL was 80 mg/kg/day. <br /> - In a 2-year chronic feeding and oncogenicity study of EPTC in <br /> mice: the NOEL was 20 mg/kg/day; the LEL was 80 mg/kg/day, and no <br /> evidence of tumorigenicity was found. <br /> - General metabolism: EPTC studies in male and female rats were <br /> reviewed and satisfied the current data requirements for animal <br /> metabolism. <br /> - Major routes of human exposure: <br /> - Current data does not indicate that the U.S. population is exposed <br /> to EPTC through the dietary or non-dietary routes. <br /> Physiological and Biochemical Behavioral Characteristics <br /> r <br /> - Foliar absorption: EPTC is absorbed mostly through the plant roots, <br /> with little or no foliar penetration. <br /> - Translocation: EPTC is readily absorbed by roots and translocated <br /> upward to the leaves and stems. <br /> - Mechanism of pesticidal action: EPTC disrupts the growth of <br /> meristematic regions of the leaves and protein synthesis. <br /> - Metabolism and persistence in plants: EPTC is rapidly metabolized <br /> by plants to CO2 and common plant constituents (amino acids and <br /> fructose) . <br /> Environmental Characteristics <br /> - Adsorption and leaching characteristics in basic soil types: EPTC <br /> is adsorbed onto dry soil. The amount of leaching decreases as clay <br /> and organic matter increase. <br /> .. - Microbial breakdown: Microbes are the primary factor in the <br /> breakdown of EPTC in soils. <br /> - Loss from photodecomposition and/or volatilization: EPTC is readily <br /> lost from volatilization unless it is immediately incorporated in <br /> the soil at time of application. <br /> - Average persistence at recommended rates: The half-life of EPTC in <br /> moist loam soil at 21 to 27 C is approximately one week. <br /> Ecological Characteristics <br /> - Avian oral LD50: > 26,000 ppm <br /> - Avian dietary LC50: > 20,000 ppm <br /> - Fish LC50: 17.0 ppm to 27.0 ppm <br /> - Problems with aquatic organisms are not anticipated, because an <br /> estimated environmental concentration of 0.141 ppm in EPTC runoff is <br /> .oll l.clr..o r1c T.Crn Fr.r �rn.�tir nrnanicmc <br /> - The low toxicity and placement of EPTC into the soil immediately <br /> prior to or just after planting should reduce exposure and provide <br /> an adequate safety margin. <br /> Tolerance Assessment <br /> Tolerances are established for negligible residues (N) of the <br /> .� herbicide s-ethyl dipropylthiocarbamate in or on the following raw <br /> agricultural commodities: <br /> Commodity Parts Per Million <br /> Almonds, hulls 0.1(N) <br /> Asparagus 0.1(N) <br /> Beans, castor 0.1(N) <br /> Cotton, forage 0.1(N) <br /> Cottonseed 0.1(N) <br /> Flaxseed 0.1(N) <br /> Fruits, citrus 0.1(N) <br /> Fruits, small 0.1(N) <br /> r. Grain crops 0.1(N) <br /> Grasses, forage 0.1(N) <br /> http://pmep.cce.comell.edu/profiles/herb-growthreg/dalapon-ethephor,/eptc/herb-prof-eptc.html 10/30/2003 <br />