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EPTC(Eptam)Herbicide Profile 10/83 Page 3 of 4 <br /> Legumes, forage 0.1(N) <br /> Nuts `/ 0.1(N) 100 <br /> Pineapples 0.1(N) <br /> Safflower, seed 0.1(N) <br /> Strawberries 0.1(N) <br /> Sunflower, seed 0.1(N) <br /> Vegetables, fruiting 0.1(N) <br /> Vegetables, leafy 0.1(N) <br /> Vegetables, root crop 0.1(N) <br /> Vegetables, seed and pod 0.1(N) <br /> �r. <br /> Problems Known to Have Occurred With Use of the Chemical <br /> The Pesticide Incident Monitoring System (PIMS) indicated at least four <br /> cases involving EPTC alone from 1966 to 1979. In these reports, <br /> agricultural workers such as mixers, loaders, and applicators received <br /> medical treatment after the pesticide contacted their eyes. The <br /> r. exposures were caused by equipment failure or splashing, and resulted in <br /> irritation, swelling, redness, and inflammation of the eyes. No <br /> fatalities were reported. PIMS is a voluntary reporting system and does <br /> not include detailed follow up or validation of reported incidents. <br /> Summary Science Statement <br /> EPTC is potentially a strong eye irritant, but it has low acute <br /> toxicities. Since EPTC is incorporated into the soil immediately or just <br /> after planting, it will not present a hazard to birds and aquatic <br /> organisms. At least two chronic toxicology studies are required to <br /> complete the data base. <br /> r <br /> 4. SUMMARY OF REGULATORY POSITION AND RATIONALE <br /> �. - Use classification: general use <br /> - Use, formulation, or geographical restrictions: No use, formulation, <br /> or geographical restrictions are required. <br /> - Unique label warning statement: None <br /> - Summary of risk/benefit review: No risk assessments were conducted. <br /> 5. SUMMARY OF MAJOR DATA GAPS <br /> - The following toxicological studies are required within four years <br /> after receipt of the guidance package: <br /> - A 1-year or longer dog feeding study <br /> A rat oncogenicity study <br /> r" - A teratology study in two species* <br /> - A 2-generation reproduction study** <br /> - The requirement for a subchronic neurotoxicity study is being deferred <br /> not i l an arntc noiirntnvi ri Yv ctnriv h.. hcan nnm-1-t-3 �n nriior f_-- <br /> determine whether the subchronic study is necessary. This study must <br /> be submitted within six months after receipt of the guidance package. <br /> - The following environmental fate data are required within four years <br /> after receipt of the guidance package: <br /> - Hydrolysis test <br /> - Photodegradation test in water <br /> - Metabolism test in anaerobic soil <br /> - Mobility (volatility) test in the lab <br /> - Dissipation study in soil <br /> - Accumulation study in combined rotational crops <br /> *A teratology study (CDL:247780) submitted by Stauffer Chemical Company <br /> is pending review by the Agency. <br /> **A reproduction study (CDL:249077) submitted by Stauffer Chemical <br /> Company is pending review by the Agency. <br /> 6. CONTACT PERSON AT EPA <br /> Robert J. Taylor <br />.� Product Manager (25) <br /> Registration Division (TS-767C) <br /> http://pmep.cce.comell.edu/profiles/herb-growthreg/dalapon-ethephon/eptc/herb-prof-eptc.htrnl 10/30/2003 <br />