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Occupational Health Guideline for - P-Dichlorobenzene - _-- INTRODUCTION prolonged or repeated contact Red blotching of the skin due to allergy to p-dichlorobenzene may occur This guideline is intended as a source of information for . Reporting signs and symptoms employees,employers,physicians,industrial hygienists, A physician should be contacted if anyone develops any and other occupational health professionals who may signs or symptoms and suspects that they are caused by have a need for such information It does not attempt to exposure to p-dichlorobenzene ' present all data, rather,it presents pertinent information . Recommended medical surveillance and data in summary form The following medical procedures should be made SUBSTANCE IDENTIFICATION available to each employee who is exposed to p-dichlor- ' obenzene at potentially hazardous levels • Formula 1,4-C LCI, L Inwal Medicaal Examination • Synonyms 1,4-Dichlorobenzene; dichlorocide; —A complete history and physical examination. The PDCB V purpose is to detect pre-existing conditions that aught • Appearance and odor Colorless solid with a moth- place the exposed employee at increased risk, and to ball-like odor establish a baseline for future health monitoring Exami- nation of the liver, respiratory tract, eyes, and kidneys ' PERMISSIBLE EXPOSURE LIMIT (PEL) should be stressed The skin should be examined for evidence of chronic disorders The current OSHA standard for p-dichlorobenzene is —Liver function tests Since liver damage has been 75 parts of p-dichlorobenzene per million parts of air observed in humans exposed to p-dichlorobenzene, a (ppm) averaged over an eight-hour work shift This profile of liver function should be obtained by using a may also be expressed as 450 milligrams of p-dichloro- medically acceptable array of biochemical test& benzene per cubic meter of air(mg/m=) —Urmalysis Measurement of 2,5-dichlorophenol may serve as an index of exposure HEALTH HAZARD INFORMATION 2. Periodic Medical Elamination: The aforementioned medical examinations should be repeated on an annual • Routes of exposure basis ' p-Dichlorobenzene can affect the body if it is inhaled or . SUMM07 Of tpxieOlW ,. if it comes in contact with the eyes or skin It can also p-Dichlorobenzene vapor irritates the eyes and upper affect the body ifit is swallowed respiratory tract and is toxic to the liver. R group of • Effects of overexposure animals repeatedly exposed to 798 ppm developed eye Exposure to p-dichlorobenzene may cause irritation of irritation, marked tremors, weakness, and loss of the eyes, nose, and throat. It may also cause headache, weight, some died Reversible, nonspecific changes in swelling around the eyes,and runny nose In addition,it the eye grounds were notal in rabbits, but there were may cause Ions of appetite, nausea, vomiting, weight no lens changes;other effects were centrolobular necro- loss,and liver damage with yellow jaundice and death sts of the liver and mild damage to thc,luiigs and Particles of solid p-dkhlorobenzene in contact with the kidneys In five cases of intoxication from enure to eyes may cause pain The solid material also produces a p-dichlorobenzene used as a mothproofing agent, one burning sensation when held in contact with the skin person with only moderate exposure coi�ismed of with slight irritation Warm fumes or strong solutions of severe headache,periorbital swelling,and pro ise rliini_ p-dichlorobenzene may'irritate the skin slightly on tis,which subsided 24 bourn after cessatibd%FWpbsure If ( - Them recommandahwo reflect good k dustnal hygle a and medical sixveilW" pracbces and thelr vplwvtvuwlion Mull assist ut achWWQ an sffsctive otxxipabonaLbeam program However, they may not be sufficient to achieve compliance = r with all regWrements of OSHA regulations tIB. DEPARFMOWWft>flALT14 AND NUMM t3Efit $ , UAL DEPA TIAE. .CW r./a RM T*SepbwAmor s a a+!s ri,,iY } ,+4Y ti@Li. . �. "�p'3Sii[ •.� 1`M