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The other four persons who had more prolonged expo- and 60 - - - . owe
<br /> sure developed anorexia, pprtn It should be recagiiized,however,that
<br /> pe xia,nausea, vomrtutg,_weaght loss, a person may-become sufficiently-accustomed-to-the
<br /> and hepatic necrosis with ,jaundice, two died, and odor to tolerate high concentrations "
<br /> another developed cirrhosis In 58 workers exposed for 2 Imtation Levels Patty states that p-dichloroben-
<br /> an average of 4 8 years(range, 8 months to 25 years)to zene"is painful to the eyes and nose at concentrations of
<br /> p-dichlorobenzene at levels of 10 to 725 ppm, there was 80 to 160m Above 160
<br /> PP ppm, it is Intolerable to any �
<br /> no evidence of hematologic effects, pamfairritshon of - person who has not worked in it long enough to have— -
<br /> the eyes and nose was recorded at levels between 50 and had some adaptation "
<br /> 80 ppm, and it was severe at 160 ppm Solid particles of 3 Evaluation of Warning Properties Through Its
<br /> p-dichlorobenzene in the human eye cause pain The odor and irritant effects, p-dichlorobenzene can be
<br /> solid material produces a burning sensation when held detected within three times the permissible-exposure
<br /> in contact with the skin, but the resulting irritation is limit. For the purposes of this guideline, therefore, it is
<br /> slight, warm fumes or strong solutions may irritate the treated as a material with good warning properties,
<br /> intact skin slightly on prolonged or repeated contact A
<br /> case of allergic purpura induced by p-dichlorobenzene MONITORING AND MEASUREMENT
<br /> has been reported In a study of workers engaged in PROCEDURES
<br /> synthesizing or otherwise handling p-dichlorobenzene,
<br /> it was concluded that urinary excretion of 2,5-dichloro- ' General
<br /> phenol (a metabolite of paradichlorobenzene)can serve Measurements to determine employee exposure are best
<br /> as an index of exposure Published studies of tests for taken so that the average eight-hour exposure is based
<br /> carcinogenicity are considered to have been too short in on a single eight-hour sample or on two fonr-
<br /> ,bott>r
<br /> duration and involved too few animals to have any samples Several short-time interval samples,(W$0 30
<br /> significance minutes) may also be used to detegnine the average
<br /> exposure level. Air samples should be taken ext, the
<br /> CHEMICAL AND PHYSICAL PROPERTIES employee's breathing zone (air that would most nearly
<br /> Physical data
<br /> represent that Inhaled by the employee)
<br /> • • Method
<br /> 1 Molecular weight 147 Sampling and analyses may be performed by collection'
<br /> 2 Boiling point(760 mm Hg) 174C(345F) of vapors using an adsorption tube with subsequent
<br /> 3 Specific gravity(water = 1) 146
<br /> 4 Va r densrt desorption with carbon disulfide and gas chromaLogra_
<br /> po y (air = I at boiling point of p- phis analysis Also, detector tubes certified bj' NI0!H
<br /> dichlorobenzene) 5 1 under 42 CFR Part 84 or other direct-reading devices
<br /> 5 Melting point 53C(127F) calibrated to measure p-dichlorobenzene may be used Y
<br /> 6 Vapor pressure at 20 C(68 F) 0 4 mm Hg An analytical method for p-dichlorobenzene,is in the
<br /> 7 Solubility in water, 9/100 g water at 20 C (68 F) NIOSH Manual of Analytical Methods 2nd Ed., Vol 3.
<br /> 0008 1977, available from the Government Pnnttpgx,QfRce,
<br />' ble Evaporation rate(butyl acetate = 1) Not applies- Washington, D.C. 20402 (GPO No. 017-U314, 0M").
<br /> • Reactivity
<br /> F�
<br /> I Conditions contributing to instability None RESPIRATORS
<br /> 2 Incompatibilities None
<br /> 3 Hazardous decomposition products Toxic gases Good industrial hygiene practices recommend that
<br /> and vapors (such as hydrogen chloride and carbon engineering controls be used to reduce envwaiimmud
<br /> monoxide) may be released in a fire involving p- concentrations to the permissible exposure level. How-
<br /> dichlorobenzene. &- , �—
<br /> ever, there are some exceptions where
<br /> 4 Special precautions. Liquid p-dichlorobenzene be used`tp control exposure. Respirators �y
<br /> will attack some forms of lash r , p� espirators tttsy�7e�ttacd
<br /> plastics,rubber,and coatings. when engineering and work practice controls arie not
<br /> •
<br /> Flammabilitylashpin technically feasible, when such controls,are•�the
<br /> 1 Flash point 65 6 C(150 F)(closed cup) process of being`mstalled,or when they faiir,"' j to
<br /> 2 Autoignition temperature Data not avadabile be supplemented- Respirators may also, ''
<br /> 3 Flammable limits in air, % by volume Lower-2 5 operations which require en
<br /> (calculated at flash point) �' into tanksor-@66d
<br /> vessels, and in emergency situations If tbe- w-of
<br /> 4 Extinguishant Foam, carbon dioxide, dry chem.
<br /> calrespirators is necemasy. the:only respiratcies=�.
<br /> ^ ' ., ,_ _ _r r tam thowduW have bem'a VMvedtby thr
<br /> Warte�g propertiessand Health`Administration (formerly Mining E`nf y
<br /> 1 Odor Threshold Patty st gent and Safety Administration) or by the Nato�Izone has a very 040T. thresh_
<br /> Instrtpto ft l}SaA4$y and
<br /> old of detraction rvlllivwy f>N0W1&tGk1Q;FPab*Mr.TheIn
<br /> «
<br /> odor becamevery�8 30 tory-p:+fi - Mai
<br /> 2 p achlorober mme �� ;
<br />
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