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Chemwatch:4650.13 Page 11 of 18 Issue Date:11/12/2018
<br /> Version No:7.1.1.1 API Pond Ammonia Test Solution#1 Print Date:06/21/2019
<br /> then enter into an equilibrium with HCN;relatively small fluctuations in pH significantly affect their biocidal properties.
<br /> Skin contact with the material may be harmful;systemic effects may result following absorption.
<br /> The material is not thought to be a skin irritant(i.e.is unlikely to produce irritant dermatitis as described in EC Directives
<br /> using animal models).Temporary discomfort,however,may result from prolonged dermal exposures.Good hygiene
<br /> practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.
<br /> The polyethylene glycols(PEGs)may be absorbed by the skin but no toxic effects have been noted and sensitisation
<br /> Skin Contact does not occur.This material may increase the absorption activity or toxicity of other ingredients in a mixture. (Source:
<br /> Genium)
<br /> Open cuts,abraded or irritated skin should not be exposed to this material
<br /> Entry into the blood-stream through,for example,cuts,abrasions,puncture wounds or lesions,may produce systemic
<br /> injury with harmful effects.Examine the skin prior to the use of the material and ensure that any external damage is
<br /> suitably protected.
<br /> Evidence exists,or practical experience predicts,that the material may cause eye irritation in a substantial number of
<br /> individuals.Repeated or prolonged eye contact may cause inflammation(similar to windburn)characterised by a
<br /> Eye temporary redness of the conjunctiva(conjunctivitis);temporary impairment of vision and/or other transient eye
<br /> damage/ulceration may occur.
<br /> On eye contact the polyethylene glycols will cause slight transient pain and conjunctival irritation although no permanent
<br /> damage.The effects are described as similar to those produced by mild soap
<br /> Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects
<br /> involving organs or biochemical systems.
<br /> Limited evidence shows that inhalation of the material is capable of inducing a sensitisation reaction in a significant
<br /> number of individuals at a greater frequency than would be expected from the response of a normal population.
<br /> Pulmonary sensitisation,resulting in hyperactive airway dysfunction and pulmonary allergy may be accompanied by
<br /> fatigue,malaise and aching.Significant symptoms of exposure may persist for extended periods,even after exposure
<br /> ceases.Symptoms can be activated by a variety of nonspecific environmental stimuli such as automobile exhaust,
<br /> perfumes and passive smoking.
<br /> There exists limited evidence that shows that skin contact with the material is capable either of inducing a sensitisation
<br /> reaction in a significant number of individuals,and/or of producing positive response in experimental animals.
<br /> There is some evidence that human exposure to the material may result in developmental toxicity.This evidence is based
<br /> on animal studies where effects have been observed in the absence of marked maternal toxicity,or at around the same
<br /> dose levels as other toxic effects but which are not secondary non-specific consequences of the other toxic effects.
<br /> Polyethylene glycols appear to act as slow-acting parasympathomimetic-like compounds.When given intravenously they
<br /> may increase the tendency of blood to clot and if given rapidly may cause cell clotting and death from embolism.
<br /> Ethylene glycol is not believed to be a metabolite
<br /> NSAIDs may cause an increased risk of serious cardiovascular thrombotic events,myocardial infarction,and stroke,
<br /> which can be fatal.
<br /> NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding,ulceration,and perforation
<br /> of the stomach or intestines,which can be fatal.
<br /> These events can occur at any time during use and without warning symptoms.
<br /> Prolonged treatment with non-steroidal anti-inflammatory drugs(NSAIDs)has been associated with gastrointestinal
<br /> irritation,erosion,ulceration,perforation,frank or occult bleeding,diarrhoea,constipation,and blood in the vomit or stool.
<br /> Kidney damage may result in haematuria(blood in the urine),pyuria(white blood cells in the urine),proteinuria(protein in
<br /> the urine),urinary casts(cylindrical aggregations of particles that form in the distal nephron,dislodge,and pass into the
<br /> Chronic urine),nocturia(excessive night time urination),polyuria(production of large volumes of pale urea),dysuria(painful or
<br /> difficult urination),oliguria(production of abnormally small volumes of urea),or anuria(inability to urinate),renal
<br /> insufficiency(insufficient excretion of wastes by the kidney),nephrosis and nephrotic syndrome(conditions characterized
<br /> by oedema and large amounts of protein in the urine and usually increased blood cholesterol),and glomerular and
<br /> interstitial nephritis.Liver effects,although rare,include jaundice,hepatocellular injury,possible fatal hepatitis,and
<br /> abnormal liver function tests.
<br /> Clinical trials of several COX-2 selective and nonselective NSAIDS of up to three years duration have shown an
<br /> increased risk of serious cardiovascular(CV)thrombotic events,myocardial infarction,and stroke,which can be fatal.All
<br /> NSAIDs,both COX-2 selective and nonselective,may have a similar risk.
<br /> NSAIDs,can lead to onset of new hypertension or worsening of preexisting hypertension,either of which may contribute
<br /> to the increased incidence of CV events.
<br /> Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury.Acute interstitial
<br /> nephritis with haematuria,proteinuria,and occasionally nephritic syndrome have been reported.
<br /> Anaphylactoid reactions may occur in patients with known prior exposure to other NSAIDs.
<br /> NSAIDs have produced ocular changes in animals and there have been reports of adverse eye findings in patients.
<br /> Anaemia is sometimes seen in patients receiving NSAIDs..This may be due to fluid retention,occult or gross GI blood
<br /> loss,or an incompletely described effect upon erythropoiesis.
<br /> In rat studies with NSAIDs,as with other drugs known to inhibit prostaglandin synthesis,an increased incidence of
<br /> dystocia,delayed parturition,and decreased pup survival occurred.
<br /> Because of the known effects of NSAIDs on the foetal cardiovascular system(closure of ductus arteriosus),use during
<br /> pregnancy(particularly late pregnancy)should be avoided..
<br /> NSAIDs inhibit enzymes collectively described as"COXs".In the course of the early search for a specific inhibitor of the
<br /> negative effects of prostaglandins which spared the positive effects,it was discovered that prostaglandins could indeed
<br /> Continued...
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