COMPLIANCE INFO_2020 - Laserfiche WebLink

Home Browse Search

Chemwatch:4650-14 Page 8 of 14 Issue Date:11/12/2018 Version No:8.1.1.1 API Pond Freshwater Nitrite Test Solution Print Date:06/21/2019 The material is not thought to produce adverse health effects or irritation of the respiratory tract(as classified by EC Directives using animal models).Nevertheless,good hygiene practice requires that exposure be kept to a minimum and Inhaled that suitable control measures be used in an occupational setting. Not normally a hazard due to non-volatile nature of product Inhalation hazard is increased at higher temperatures. The material has NOT been classified by EC Directives or other classification systems as"harmful by ingestion".This is because of the lack of corroborating animal or human evidence.The material may still be damaging to the health of the individual,following ingestion,especially where pre-existing organ(e.g liver,kidney)damage is evident.Present Ingestion definitions of harmful or toxic substances are generally based on doses producing mortality rather than those producing morbidity(disease,ill-health).Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however,ingestion of insignificant quantities is not thought to be cause for concern. The material may cause skin irritation after prolonged or repeated exposure and may produce a contact dermatitis (nonallergic).This form of dermatitis is often characterised by skin redness(erythema)and swelling epidermis. Skin Contact Histologically there may be intercellular oedema of the spongy layer(spongiosis)and intracellular oedema of the 9� Y Y P 9Y Y epidermis. The material may be irritating to the eye,with prolonged contact causing inflammation.Repeated or prolonged exposure to Eye irritants may produce conjunctivitis. Long-term exposure to the product is not thought to produce chronic effects adverse to health(as classified by EC Chronic Directives using animal models);nevertheless exposure by all routes should be minimised as a matter of course. API Pond Freshwater TOXICITY IRRITATION Nitrite Test Solution Not Available Not Available TOXICITY IRRITATION dermal(rat)LD50:>2000 mg/kgI1I Eye(rabbit):500mg/24h-mild. polyethylene glycol Oral(rat)LD50:600 mg/kg[2] Eye:no adverse effect observed(not irritating)[11 Skin(rabbit):500mg/24h-mild. Skin:no adverse effect observed(not irritating)[1 TOXICITY IRRITATION Dermal(rabbit)LD50:>5010 mg/kg[2] Eye(rabbit):5mg/30s-mild MURIATIC ACID Inhalation(rat)LC50:780.108879 mg/I/lh[2] Eye:adverse effect observed(irritating)['] CONCENTRATE Oral(rat)LD50:=700 mg/kg[2] Skin:adverse effect observed(corrosive)['] Skin:adverse effect observed(irritating)['] Legend: 1. Value obtained from Europe ECHA Registered Substances-Acute toxicity 2. Value obtained from manufacturer's SDS. Unless otherwise specified data extracted from RTECS-Register of Toxic Effect of chemical Substances for polyethylene glycols Pure polyethylene glycols have essentially similar toxicity,with toxicity being inverse to molecular weights.Absorption from the gastrointestinal tract decreases with increasing molecular weight The G.I.absorption of a series of polyethylene glycols has been studied.Polyethylene glycols having average molecular weights of 4000 and 6000 showed no absorption from the rat intestine over a five-hour period,while polyethylene glycols of 1000 and 1540 molecular weights showed a slight absorption amounting to less than 2%of the total dose during the same period.When 1 g doses of polyethylene glycols of molecular weight 1000(PEG 1000)and 6000(PEG 6000)were given intravenously to six human subjects,85%of PEG 1000 and 96%of PEG 6000 were excreted in the urine in 12 hours.When these two same materials in 10 g doses were given orally to five human subjects,none of the PEG 6000 was found in the urine in the following 24 hours,whereas about 8%of PEG 1000 administered was found to excrete in urine within 24 hours When PEG 400 was given intravenously to three human subjects,an average of 77%recovery of this material was found in the urine in 12 hours.However,when the same substance was given orally to the same three human subjects,a recovery of between 40 and 50%of the dose was determined in the urine in the course of the following POLYETHYLENE GLYCOL 24 hours.Single oral doses of PEG 400 were incompletely recovered from urine and faeces of rabbits even when collection of excreta was continued as long as four days following the dose.Evidence from all these and other studies indicate that ethylene glycol is not formed as a metabolite of PEG 400 Prolonged skin contact of PEG 1500 and 4000 upon the skin of rabbits in dosages of 10 g/kg bw showed no deleterious effects on internal organs and little,if any,of the materials was absorbed through the skin. Although early reports indicated that skin sensitization was observed among a few human subjects and in guinea pigs tested with certain polyethylene glycols,later studies showed that currently produced materials were without irritating or sensitizing properties.However,recent report(Fischer, 1978)demonstrated that four patients showed allergic reactions to lower molecular weight liquid polyethylene glycols in topical medications.Two had immediate urticarial reactions to PEG 400.Two other patients had delayed allergic eczematous reactions,one to PEG 200,and one to PEG 300. Polyethers,for example,ethoxylated surfactants and polyethylene glycols,are highly susceptible towards air oxidation as the ether oxygens will stabilize intermediary radicals involved. Investigations of a chemically well-defined alcohol (pentaethylene glycol mono-n-dodecyl ether)ethoxylate,showed that polyethers form complex mixtures of oxidation Continued...