COMPLIANCE INFO_2010 - Laserfiche WebLink

Home Browse Search

41 LUPEROX DELTA Material Safety Data Sheet ATOFINA Chemicals, Inc. l 11 TOXICOLOGICAL INFORMATION � — 2,2,4-Trimethyl-l,3-Pentanediol Diisobutyrate Single exposure (acute)studies indicate that this material is no more than slightly toxic to rats if swallowed (LD50 >3,200 mg/kg), practically non-toxic to guinea pigs if absorbed through skin (LD50 >20 ml/kg) or rats if inhalec (6-hr LC50= .3 mg/l) and slightly irritating is rabbit eyes and to guinea pig skin No skin allergy was observed in guinea pigs following repeated exposure. Increased liver weights, which were probably adaptive changes due to the induction of drug metabolizing enzymes in these tissues, were observec in rats or dogs fed up to 1% in their feed for up to 103 days. This material is eliminated in the excreta of rats following a single oral dose with little or no retention in the tissues or organs. Hydrogen Peroxide Single exposure(acute)studies indicate that this material is moderately toxic to rats if swallowed (LD50 75 mg/kg; 70% solution), practically non-toxic to rabbits if absorbed through skin (LD50 >6500 mg/kg; 70% solution), slightly toxic to rats if inhaled (4-hr LC50 2 mg/1), and corrosive to rabbit skin and eyes. No skin allergy was observed in guinea pigs following repeated exposure. Solutions of 3-6% are commonly used for disinfecting wounds, bleaching hair or as a mouth wash and generally do not show adverse skin reactions. Accidental ingestion of 30-40% solutions by children has resulted in death from lung edema, stomach erosions and gas distention and burns to the throat and esophagus. Eye and throat irritation and bleaching of hair have been reported by workers exposed to 9-30 ppm in the atmosphere. Several studies have been conducted via administration in the drinking water of mice and rats. The primary findings were reduced body weight gain or early deaths at high dose levels. Subchronic gavage dosing at high dose levels caused decreases in red blood cell count and hemoglobin concentrations, reduced body weight and some alterations in organ weights that were not accompanied by histopathological changes. Subchronic exposure of rats and mice to 22-77 ppm caused nasal irritation without notable adverse effects on the lining of the upper respiratory system. Six-month exposure of dogs to 7 ppm resulted in upper respiratory tract irritation and emphysematous changes in the lungs. Longer-term oral administration to mice at 0.15% resulted in adverse effects on the liver, kidney, gastrointestinal tract and spleen. Generally, long-term gavage dosing did not cause any adverse effects other than erosion of the stomach duodenal lining from direct application of the test material. Several studies have shown an increase in gastrointestinal tract tumors in mice and rats chronically exposed in the drinking water. Initiation-promotion studies conducted by skin painting or dosed drinking water indicate that concentrations greater than 15% (which caused skin irritation) may be weak tumor promoters. Concentrations less than 1% do not promote gastrointestinal tumors. The U.S. Federal Drug Administration has concluded that there is insufficient evidence of carcinogenicity and the International Agency for Research on Cancer(IARC) has concluded that there is limited evidence of carcinogenicity in experimental animals. Pregnant rats fed a diet containing 10% showed decreased maternal and fetal weights, but no increase in birth defects was noted. Genetic changes were observed in tests using bacteria and animal cells, but not in whole animals. Methyl Ethyl Ketone Single exposure (acute)studies indicate that this material is no more than slightly toxic to rats if swallowed (LD50 2,700-5,600 mg/kg), practically non-toxic to rabbits if absorbed through skin (LD50 5,000-13,000 mg/kg) or rats if inhaled (4-hr LC50 11,700 ppm), and moderately irritating to rabbit eyes and skin. Repeated exposure of humans to controlled skin contact studies with this material produced no skin irritation or skin allergy. Central nervous system (CNS) effects and peripheral neuropathy have been reported in the industrial setting following exposure to mixtures containing this material; however, these mixtures contained other solvents known to cause nervous sytem injury. Following repeated inhalation exposure, slight changes in organ weights and blood chemistry were reported in Product Code: 114000 Revision: 3 Issued:16 FEB 2001 Page 6 of 10