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Human Health Screening Evaluation <br /> US Can—Welty Road March 19,2012 <br /> SFo =oral cancer slope factor, (milligrams per kilogram [mg/kg]-day)-1 <br /> 1 Cs =concentration in soil, mg/kg <br /> ABS =dermal absorption fraction, dimensionless <br /> The oral and dermal cancer risk calculations for potential exposures to on-site soils are provided <br /> in Table 11. SAIC estimated potential cancer risks for carcinogenic PAH COPCs, and summed <br /> the risks among chemicals for oral and dermal exposures. <br /> Inhalation Cancer Risks for Air(PEA Guidance Manual, Figure 2.4): <br /> Riska„-=SH x Ca x 0.149 <br /> Where: <br /> Riskair inhalation cancer risk from indirect soil exposure <br /> SFi= inhalation cancer slope factor, (mg/kg-day)-1 <br /> Ca=concentration in air, milligrams per cubic meter(mg/m3) <br /> Section 3.4.3 describes how SAIC estimated the value for Ca using equations presented in PEA <br /> Guidance Manual Figures 2.5, 2.6, and 2.7 for VOCs, and Figure 2.8 for non-VOCs. <br /> The inhalation cancer risk calculations for potential exposure to on-site soils are provided in <br /> Table 12. SAIC estimated the potential cancer risks for carcinogenic PAH COPCs, and summed <br /> the risks among chemicals for inhalation exposures. <br /> ' SAIC then summed the cancer risks for oral and dermal exposures (Table 11)with the risks for <br /> inhalation exposures (Table 12) to estimate the cancer risks across exposure routes for soil. The <br /> 1 sum of oral, dermal, and inhalation cancer risks for on-site soils are provided in Table 13. <br /> 3.4.2 Non-Cancer Health Hazards from Constituents of Potential Concern in Soil <br /> ' SAIC calculated the estimated oral/dermal and inhalation non-cancer hazards for exposure to on- <br /> site soils for potential on-site residential receptors using the following equations: <br /> Oral and Dermal Hazards for Soil(PEA Guidance Manual, Figure 2.3): <br /> ' Hazardso;j_([Cs/RfDo] x [1.28E-051)+ ([Cs/RfDo] x [1.28E-04] x ABS) <br /> Where: <br /> Hazardsoil=oral and dermal non-cancer hazards from direct soil exposure <br /> Cs =concentration in soil, mg/kg <br /> ' RfDo=oral reference dose, in units of mg/kg-day <br /> ABS =dermal absorption fraction, dimensionless <br /> ' The oral and dermal hazard calculations for potential exposure to on-site soils are provided in <br /> Table 14. Potential non-cancer hazards were estimated for PAH COPCs and then summed <br /> among chemicals for oral and dermal exposures. <br /> ' 7 <br /> SAIC <br />