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ARkEMA SAFETY DATA SHEET RILSANO 5956 GREY RDP 15-10 ES Carcinogenicity Chronic dietary administration to rat and mouse/signs: No increase in tumor incidence was reported. Chronic inhalation administration to rat/affected organ(s): lung /signs: Increase in tumor incidence was reported. Classified by the International Agency for Research on Cancer as: Group 213: Possibly carcinogenic to humans. Genotoxicity Assessment in Vitro: No genetic changes were observed in laboratory tests using: bacteria, animal cells, yeast Genotoxicity Assessment in Vivo: No genetic changes were observed in laboratory tests using: mice, rats Other information The information presented is from representative materials in this chemical class. The results may vary depending on the test substance. Human experience Skin contact: Skin: No skin allergy was observed. (studied using human volunteers) Data for C.I. Pigment Blue 28 (1345-16-0) Acute toxicity Oral: No deaths occurred. (rat) LD50> 10,000 mg/kg. Carcinogenicity Long term implantation administration to rodent/affected organ(s): site of contact /signs: Increased incidence of tumors was reported. Chronic inhalation administration to animals/affected organ(s): lung /signs: Increased incidence of tumors was reported. Classified by the International Agency for Research on Cancer as: Group 2B: Possibly carcinogenic to humans. (cobalt compounds) Genotoxicity Assessment in Vitro: Both positive and negative responses for genetic changes were observed in laboratory tests on similar li materials using: bacteria, animal cells Genotoxicity I Assessment in Vivo: Both positive and negative responses for genetic changes were observed in laboratory tests using: rats, mice, (data for similar material) Developmental toxicity Product code: A09469 Version 1.0 Issued on: 05/15/2015 Page: 11 /16 Quick-FDS[17303-32698-27051-016798]-2015-05-16-09:04:58