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AR,k MA SAFETY DATA SHEET <br /> RILSANO 5956 GREY RDP 15-10 ES <br /> Assessment in Vitro: <br /> No genetic changes were observed in laboratory tests using: bacteria, animal cells, human cells <br /> Developmental toxicity <br /> Exposure during pregnancy. dietary(sheep)/bone effects in Iambs(at doses that produce effects in mothers, <br /> blood chemistry changes) <br /> Exposure during pregnancy. dietary(rat)/No birth defects were observed. <br /> Reproductive effects <br /> Reproductive/Developmental Effects Screening Assay. oral (rat)/No toxicity to reproduction <br /> Human experience <br /> General: <br /> Dust contact with the eyes can lead to mechanical irritation. Contact with dust can cause mechanical irritation <br /> or drying of the skin. <br /> Human experience <br /> Inhalation: <br /> Upper respiratory tract: Local irritation, coughing. (dust) (severity of effects depends on extent of exposure) <br /> Human experience <br /> Ingestion: <br /> Kidney: failure,weakness, nausea. (effects of excessive exposure) <br /> Data for Titanium oxide(TiO2)(13463-67-7) <br /> Acute toxicity <br /> Oral: <br /> No deaths occurred. (rat) LDO>5,000 mg/kg. <br /> Dermal: <br /> Practically nontoxic. (rabbit) LD50 > 10,000 mg/kg. <br /> Inhalation: <br /> Practically nontoxic. (rat)4 h LCO>6.82 mg/I. <br /> Skin Irritation: <br /> Practically non-irritating. (rabbit) Irritation Index: 0-0.28/8.0. <br /> Eye Irritation: <br /> Causes mild eye irritation. (rabbit) <br /> Skin Sensitization: <br /> Not a sensitizer. LLNA: Local Lymph Node Assay. (mouse) No skin allergy was observed <br /> Not a sensitizer Buehler Test. (guinea pig) No skin allergy was observed <br /> Repeated dose toxicity <br /> Subchronic inhalation administration to rat/affected organ(s): respiratory tract /Local irritation of the <br /> respiratory system <br /> Subchronic oral administration to rat/No adverse effects reported. <br /> Product code:A09469 Version 1.0 Issued on: 05/15/2015 Page: 10/16 <br /> Quick-FDS[17303-32698-27051-016798]-2015-05-16-09:04:58 <br />