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_ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 724060 - Unbranded Gasoline Reformulated with Ethanol Page 6/10 Issue Date: 20-Jun-2016 Status: FINAL SECTION 10: Stability and reactivity Reactivity: Not chemically reactive. Chemical stability: Stable under normal ambient and anticipated conditions of use. Possibility of hazardous reactions: Hazardous reactions not anticipated. Conditions to avoid: Avoid high temperatures and all sources of ignition. Prevent vapor accumulation. Incompatible materials: Avoid contact with strong oxidizing agents and strong reducing agents. Hazardous decomposition products: Not anticipated under normal conditions of use. SECTION 11: Toxicological information Information on Toxicological Effects Substance / Mixture Aspiration Hazard: May be fatal if swallowed and enters airways Skin Corrosion/Irritation: Causes skin irritation. Repeated exposure may cause skin dryness or cracking. Serious Eye Damage/Irritation: Causes eye irritation. Skin Sensitization: Not expected to be a skin sensitizer. Respiratory Sensitization: No information available. Specific Target Organ Toxicity (Single Exposure): May cause drowsiness and dizziness. Specific Target Organ Toxicity (Repeated Exposure): Not expected to cause organ effects from repeated exposure. Two year inhalation studies of wholly vaporized unleaded gasoline, and 90 days studies of various petroleum naphthas, did not produce significant target organ toxicity in laboratory animals. Nephropathy in male rats, characterized by the accumulation of alpha-2-u- globulin in epithelial cells of the proximal tubules was observed, however follow-up studies suggest that these changes are unique to the male rat. Carcinogenicity: May cause cancer. Based on component information. Two year inhalation studies of vaporized unleaded gasoline produced an increased incidence of kidney tumors in male rats and liver tumors in female mice. Repeated skin application of various petroleum naphthas in mice for two years resulted in an increased incidence of skin tumors but only in the presence of severe skin irritation. Follow-up mechanistic studies suggest that the occurrence of these tumors may be the consequence of promotional processes and not relevant to human risk assessment. Epidemiology data collected from a study of more than 18,000 petroleum marketing and distribution workers showed no increased risk of leukemia, multiple myeloma, or kidney cancer from gasoline exposure. Unleaded gasoline has been identified as a possible carcinogen by the International Agency for Research on Cancer. Germ Cell Mutagenicity: Not expected to cause heritable genetic effects. Gasoline was negative in microbial mutagenicity and unscheduled DNA tests in rat hepatocytes. Gasoline did not induce chromosome aberrations in vivo in rat bone marrow cells and was negative in a mouse dominant lethal assay. Reproductive Toxicity: Not expected to cause reproductive toxicity. No evidence of developmental toxicity was found in pregnant laboratory animals (rats and mice) exposed to high vapor concentrations of unleaded gasoline and petroleum naphthas via inhalation. A two-generation reproductive toxicity study of vapor recovery gasoline did not adversely affect reproductive function or offspring survival and development. Acute Toxicity Hazard Additional Information LC50/LD50 Data Inhalation Expected to have a low degree of toxicity by inhalation >5.2 mg/L (vapor) Dermal Unlikely to be harmful 3.75 g/kg Oral Unlikely to be harmful 14 g/kg