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W-11 `1_11 <br /> 4 _ . <br /> yg�g <br /> og <br /> s, 9. ROMEO L - <br /> e <br /> -EL OILS <br /> 66-21 <br /> duration of exposure, <br /> Dose-adicace chat related -.�if'ects in neurological testis <br /> the uncompusted diesel vapors may also g <br /> ^eurodepressartc (2334}. <br /> act as a <br /> In acute dermal studies conducted in rabbits, <br /> Oil (APT gravzty 5.2/1,23 sulfur) induced significant -signs <br /> 6 heavy fuel <br /> at 5 g/kg, It caused severe dermal irritation, vel of toxicity <br /> ataxia and lethargy, Hortali „as 6hc loss, <br /> toxic hepatitis, CY 37.51• Necro s anorexia, <br /> gascrointes[iaal irritation and con revealed scuta <br /> Other grades of number 6 and rumber 2 oils as well <br /> assced lungs. <br /> produced mild to moderate dermal as but no systemic;signs oil <br /> toxicity (1424), <br /> In the subacute da <br /> were applied co anal study, doses ranging from 1 to 10 mLlkg <br /> bandaged for 24 hoursatclipped free of hair. Tho area <br /> dose a hick time the patch were removed andmainew <br /> applied. •Chis continued for 5 consecutive dav, <br /> day rest period and a followed by a 2 <br /> + <br /> chis test. reheat application for 5 consecuci7e, days, <br /> the number 6 Eual oil (API gravity 5.1/1.23 sulfur) oro.. I <br /> the greatest degree of toxicity ac the Lowest dose (75t mortality ed <br /> +. 2.5 mL/kg). Clinat <br /> ical signs ineLuded severe rel ht loss. <br /> J signs of dermal lrricacion. g anorexia and <br /> gastroenteritis, Gross necropsy revealed <br /> and congested, mottled livers with multefocalmnecrosis <br /> and cancrilobular vacuolar degeneration. <br /> Oils caused inflammation, dermal congestion and l cases. <br /> the number 6 <br /> acanthosis and parakeratosis, al necrosis, <br /> also seen b Liver necrosis and degeneration were <br /> but the severity was <br /> sulfur_ All 3 number 2 ails, causnot as great as char with 5.1/1.21 <br /> ed weight loss, anorexia and various <br /> degrees of dermal irritation. At a dose of 10 mL/kg. <br /> from 75 to 1001_ Grass <br /> renal and hepatic y l <br /> necropsy mortality ranged <br /> congescion. At the iOmL/k at all <br /> sage Levels included <br /> hepatic necrosis was observed (1924) g level, multifocal <br /> Ln primary dermal <br /> moderates sthe nu <br /> irritation testnumber2 oils were <br /> Y irritating while the number 6 <br /> slightly irritatin Diesel o�,ls were minimally cc <br /> included sew Euei vas extremely irricating, <br /> era erytt hema and dema with blistering Signs <br /> applying 0.5 <br /> test was conducted by applmL of undilu[d a materialstoeabraded <br /> rabbit skin. The test - <br /> bands e v as then covered for 2L <br /> 3 as hours at which point the <br /> recnnique (1924removed and the animals scored according cc Che Draize <br /> ) <br /> The number 6 oils were minimally to moderately irritating when O,L <br /> ML vas appLied cc rabbit eves. <br /> redness, swelling Wiese materials produced conjunctival <br /> t but a and .discharge. Few corneal <br /> Yes returned co normal 1' Opacities '.ere produced <br /> non-irricatin and 2 Rhin 72 hours. Diesel _uel was <br /> Co mildly Lrritatinnumbe' ) oils ranged from practically non-irricating <br /> 5 (19_4 <br /> 6/87 <br />