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..'!.d?'. <br /> NMI <br /> W :.. <br /> I <br /> III <br /> 1 <br /> 9 <br /> 9 <br /> FUEL OIIS <br /> 66-27 <br /> seen in the heart, lung, liver, kidnev and brain. A one-hour vapor <br /> exposure to 25,752 ppm caused rapid narcosis and tre=or and was lethal <br /> to all exposed rabbits. In mice, <br /> from 14,600 to 122.000 ppm. concentrations causing narcosis vary <br /> - <br /> Cyclohexane is no absorbed through the skin although <br /> massive applications (> 180,2 g/kg) to rabbit skin resulted in <br /> microscopic changes in the liver and kidneys and caused the death of <br /> all animals. <br /> The danger of chronic poisoning is reUrively slight becauza this oxic <br /> compound is almost completely eliminated from the body. Ito t <br /> changes were seen in rabbits exposed to vapor levels of 434 ppm, 6 <br /> the hours daily for SO exposures, but some microscopic changes were seen in <br /> liver and kidneys when the exposure was to 786 ppm for, the same <br /> period_ <br /> In man, no syscemic poisonings by cvclohexmne have been reported. <br /> A vapor level of 300 ppm is samewhac irritating to the eyes and mucous <br /> membranes. It has been reported that cyclohexane may potentiate the <br /> toxic effects of TOCP but no additional details of this interaction are <br /> available (12,17,46,54.1937). <br /> Ben_ zone <br /> The primary effects of benzene inhalation and ingestion are on the <br /> • central nervous system (54). Benzene is carcinogenic in both animals <br /> and man. Several reports have established a relationship between <br /> benzene exposure and leukemia. For more information, refer to Chapter <br /> I8 of the Installation Restoration Program Toxicology Cuide, Volume L. <br /> Tn uene <br /> rv � Toluene is a CNS depressant with a low toxicity. For more <br /> information, refer to Chapter 19 of the Installation Restoration <br /> Program Toxicology Guide. Volume 1. <br /> l <br /> jxLenen <br /> Acute exposure to high concentrations of xyle.-a vapors may cause <br /> CNS depression. Both the liquid and the vapor are irritating to the <br /> eyes, mucous membranes and skin (46). The National Toxicology Program <br /> recently reported that there was no evidence of carcinogenicity of <br /> i mixed xylenes in either mice or rats given daily doses ranging from 250 <br /> co 1000 mg/kg by gavage for 2 years (1939). <br /> r <br /> For more information, refer to Chapter 21 o£ the Installation <br /> 1 Restoration Program Toxicology Guide, Volume 1. <br /> r <br /> — _ 6/87 <br />