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w <br /> -'MH <br /> r u z,., OILS <br /> 56-25 <br /> Ethyl ben-eae is prisari,y an i^-:tsac .o �'ae skin. <br /> resairas:ory tract_ Systemic <br /> absorption Causes denressioa 6) <br /> rQ<S UC or <br /> - <br /> For more +alarn+aLian. refer to Ch iter 20 oz tam =nzcalla.ian <br /> o <br /> "Zest program Toxicology Guide vaivae 1- <br /> Tr`'-ct be es <br /> The tZi—r-hylbenzenes occur in 3 isomeric. -aG=s. the 1,3,5-isoator <br /> (Qesitylcae) and the 1,2,4-isomer (pseudocumene) are toricologita7ly <br /> Similar. H;.gh vapor concentrations (5000-9000 ppm) <br /> depression in aairasls- Loss of reflexes was seen cat:.se Cris <br /> i3 nice Q--Posed to <br /> 8130-9140 ppm of the 1.2,4-isomer or 8130 ppm of the 1.3.5-isomer. <br /> Bats exposed to 2700 ppm o£ an isomeric aisture for 10-21 dans had no <br /> adverse effects or fatalities. <br /> The fatal iatraperironeal dose of tae ?.,2,4-isomer for the guinea <br /> Pig is 1.788 g/kg, while the fatal dose az" tae -1,3,5-isomer by the same <br /> /L <br /> route is 1-5-2 go for rhe rat. For the 1.2.3-isomer'. an oral IAI.o of <br /> 5000 mg/kg has been reported in the rat. Tziaechyiberzenc liquid is a <br /> primary skin irritant. Deposition into the lungs causes -z euuanitis at <br /> the site of conC3Ct. <br /> The an-Y report of huzan exposure described symptoms of <br /> nervousness, tension, a�ezv, amth- tic bronchitis, hypochromic anemia <br /> and changes in the cos <br /> ,.., ranged from 10-60 coagulability of the blood. Vapor concentrations <br /> PPM. Exposure was to a mixture containing 30% o; the <br /> 1.3.3-isomer and 503 of the 1.2,4-isomer (2,7.2). <br /> k[eth�l a hrhalene <br /> The only adverse effects of merhvin nhzhalene renorrad in man are <br /> skin izrizacion and, phocosensitization (17). Oral LD.. values of 1840 <br /> -mg/kg ass# 1630 mg/kg have been reported for 1-mechvInapathalene and <br /> 2-merhylnaphr_halene, respectively, 3-n the rat <br /> . �7anf�ch:x?°ne <br /> Ingestion or prolonged inhalation of naphthalene produces nausea, <br /> vomiting, and, disorientation- It is irritating co the skin and eyes and <br /> prolonged vapor e=o4ure has led to cataract farmne;an is ^asps f17), <br /> :iemolytie anemia is the most severe eifecc associated ::n naphthalene <br /> exposure. but tris ezfecc is seen predominancly in ind°victuals with an <br /> enzyme deficiency (54) <br /> For more iniormation, refer to C:=ocer 32 of r-he =:u.tallation <br /> Rescorazion Toxicology Guide, Volume 1. <br /> i <br />