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TEL oIIS 66.27 <br /> seeat in the heart. lung, liver. kidaev and brain. A. one-hour vapor <br /> exposure co 26.752 PPM caused rapid narcosis and tremor and was lethal <br /> co all exposed rabbits. Iu mice. caaceacrasions causing sarcosis ma=y <br /> from 14.600 co 122.000 gpm_ <br /> Gahexsna is nominally absorbed through the skin altho <br /> massivee applieatians ugh(> 130.2 g/kg) to rabbit skin rezulrad is <br /> microscapie changes in the liver and kidnevs and caused the death of <br /> all animals. <br /> The danger of chronic poisoning is relatively slight becaus, eh#s <br /> compound is almost completely elitainated from the body. No toxic <br /> changes were seen in rabbits exposed• co vapor levels £ 434 ppa� b <br /> hours daily for 50 eo <br /> 'exposures, but soma mieroscopic ch=S o vara "en is `r <br /> the liver and kidneyx when the exposure was co 78b ppm for iiia s:aa <br /> period. <br /> In mea. no systemic poisaaings by cyclohexane have been reported. <br /> vapor level of 300 ppm is somevinat irritating to the eyes and mucous <br /> membranes_ IC has been reported• that cyclohexane may porencfaca the <br /> toxic effects of TOCP but no additional details of this interaction are <br /> available (12.17.46,54. 1937) , <br /> Benzene <br /> The Pr'mary effects of benzene inhalation and ingestion are an the <br /> central nervous system (54) . <br /> andSenxene is carcinogenic in both animals <br /> . Several reports have established a relationship between <br /> benzene exposure and leukemia. for more information. <br /> refeto <br /> 18-of the Installation Rescaration Program roxicology C ider Volume Chapder <br /> Toluene <br /> Toluene Ls a CHS depressant with a low toxicity. For more <br /> information. refer to Chapter 19 of the installation RescoratioYt <br /> Program Toxicology Guide. volume 1_ <br /> Xylenes <br /> Acute exposure co high concencracions of xylene vapors may cause <br /> CNS depression. Both the liquid and the vapor are irri.zacing to the <br /> eyes. raucous membranes and skin (46) . The Nacional Toxicology <br /> recently reported that rata <br /> there was "no ProgThe <br /> of carcinogenicity of <br /> mixed xylenes in either mice or rats given daily doses ranging from 250 <br /> to 1000 mg/kg by gavage for 2 years (1939) . <br /> For more Lnformatzon• refer to Chanter 21 of the Installation <br /> Restoration Program Toxicology Guide. Volume L_ — <br /> 6/87 i <br />